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Poor lung function may predict future arterial stiffness

17 Aug 2019

Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.

Researchers used data from the Whitehall II cohort study and included 5,342 individuals (mean age, 65.4 years; 26 percent female) in the analysis. All participants completed repeated assessments of forced expiratory volume in 1 second (FEV1) and carotid-femoral pulse wave velocity (cf-PWV) over 5 years.

Individuals who showed greater FEV1 decline tended to be older, male and White, and were more likely to have higher cf-PWV values at baseline. Of note, greater FEV1 decline correlated with current smoking, higher waist circumference, higher systolic blood pressure, higher mean arterial pressure and lower heart rate.

Multivariable analysis using linear mixed-effects modelling revealed that poorer pulmonary function was associated with later elevation in cf-PWV and its subsequent progression (cf-PWV 5-year change per 1-standard deviation lower FEV1, 0.09 m/s, 95 percent CI, 0.03–0.17; p=0.011).

Furthermore, arterial stiffness was more pronounced in the top vs bottom quartile of FEV1 decline (median, –0.53 vs 0.57 litres; difference in cf-PWV at baseline, 0.17 m/s, 0.04–0.30; p=0.011).

There was no evidence to support mediation by circulating C-reactive protein or interleukin-6.

The present data support pulmonary function as a clinically important risk factor for arterial stiffness, the researchers said. More studies are warranted to evaluate interventions for pulmonary function in relation to arterial stiffness.

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Most Read Articles
Pearl Toh, 20 Nov 2019
The trade-off between the risk of ischaemic vs bleeding events may be different between Asian and non-Asian patients, which warrants careful consideration when deciding on the duration of antiplatelet therapy following a percutaneous coronary intervention (PCI), according to a presentation at ESC Asia Congress 2019.
2 days ago
Participating in a long-distance skiing event may help lower the risk of hypertension, with the number of completed races showing a weak association with the risk, a study has found.
06 Sep 2019
Hypertensive adults with lower plasma zinc concentration are at increased risk of haemorrhagic stroke, especially those with higher body mass index or lower plasma copper levels, a study has found.
06 Jan 2020
Target organ damage appears to be more noticeable in patients affected by primary aldosteronism than those affected by arterial hypertension without primary aldosteronism, suggests a study, adding that specific treatment can ease such condition.