Poor lung function may predict future arterial stiffness
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Researchers used data from the Whitehall II cohort study and included 5,342 individuals (mean age, 65.4 years; 26 percent female) in the analysis. All participants completed repeated assessments of forced expiratory volume in 1 second (FEV1) and carotid-femoral pulse wave velocity (cf-PWV) over 5 years.
Individuals who showed greater FEV1 decline tended to be older, male and White, and were more likely to have higher cf-PWV values at baseline. Of note, greater FEV1 decline correlated with current smoking, higher waist circumference, higher systolic blood pressure, higher mean arterial pressure and lower heart rate.
Multivariable analysis using linear mixed-effects modelling revealed that poorer pulmonary function was associated with later elevation in cf-PWV and its subsequent progression (cf-PWV 5-year change per 1-standard deviation lower FEV1, 0.09 m/s, 95 percent CI, 0.03–0.17; p=0.011).
Furthermore, arterial stiffness was more pronounced in the top vs bottom quartile of FEV1 decline (median, –0.53 vs 0.57 litres; difference in cf-PWV at baseline, 0.17 m/s, 0.04–0.30; p=0.011).
There was no evidence to support mediation by circulating C-reactive protein or interleukin-6.
The present data support pulmonary function as a clinically important risk factor for arterial stiffness, the researchers said. More studies are warranted to evaluate interventions for pulmonary function in relation to arterial stiffness.