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3 days ago
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Poor HDL functionality bears heightened risk of acute coronary syndromes

29 Jan 2020

Several high-density lipoprotein (HDL) functionality parameters, which are linked to HDL roles on cholesterol metabolism, endothelial protection and antioxidant/anti-inflammatory defence, contribute to an increased risk of incident acute coronary syndromes (ACS) and its manifestations in individuals at high risk of cardiovascular disease, a study reports.

The current case-control study was nested within the PREDIMED cohort, a trial evaluating the effects of Mediterranean vs low-fat diet. The population comprised 167 patients with incident ACS and 333 non-ACS controls. ACS patients were more likely to use glucose-lowering drugs (p<0.001), be current smokers (p=0.013) and have greater systolic blood pressure levels (p<0.001).

Researchers measured the following HDL functional characteristics: HDL cholesterol concentration (in plasma); cholesterol efflux capacity; antioxidant ability measured by the HDL oxidative-inflammatory index; phospholipase A2 activity; and sphingosine-1-phosphate, apolipoproteins A-I and A-IV, serum amyloid A, and complement 3 protein (in apolipoprotein B-depleted plasma).

Multivariable conditional logistic regression models showed ACS risk to be associated with low values of cholesterol efflux capacity (odds ratio [OR], 0.58) and levels of sphingosine-1-phosphate (OR, 0.70) and apolipoprotein A-I (OR, 0.58). Higher HDL oxidative inflammatory index values had a marginal association with the risk (OR, 1.27).

On further analysis, low values of cholesterol efflux capacity (OR, 0.33), sphingosine-1-phosphate (OR, 0.60) and apolipoprotein A-I (OR, 0.59) were specifically related to myocardial infarction. On the other hand, high HDL oxidative-inflammatory index values (OR, 1.53) and low apolipoprotein A-I levels (OR, 0.52) were linked to unstable angina.

The findings may prove valuable for the discovery of novel prognostic biomarkers or potential therapeutic targets of cardiovascular disease related to HDL function, according to the researchers.

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Most Read Articles
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).
2 days ago
Cuff-based excess pressure (XSP) is modestly associated with carotid intima–media thickness independent of conventional risk factors, reveals a recent study.