Poor glycaemic control tied to sarcopaenia in diabetics
Poor glycaemic control appears to correlate with low muscle mass in patients with type 2 diabetes, reports a new study.
The study included 746 type 2 diabetes patients (mean age, 69.9±9.1 years) who were compared against 2,067 elderly general population controls. Sarcopaenia was defined as slow usual gait speed, low skeletal mass index or weak grip strength.
Of the diabetic participants, 7.0 percent (n=52) were diagnosed with sarcopaenia. Stratifying the participants according to glycated haemoglobin (HbA1c) showed a direct and linear correlation with sarcopaenia prevalence.
For instance, in those with HbA1c <6.5 percent, the corresponding prevalence rate was 2.5 percent. This rose to 7.3 percent, 7.5 percent and 10.0 percent in the HbA1c categories ≥6.5 percent to <7.0 percent percent, ≥7.0 percent to <8.0 percent and ≥8.0 percent, respectively (p=0.053).
Logistic regression analysis showed that positive correlation between HbA1c and sarcopaenia was independent of confounders such as age, sex, body mass index, exercise habit, insulin therapy, cardiovascular diseases, and duration of diabetes and retinopathy, among others.
The fully adjusted model, for example, showed that the likelihood of sarcopaenia rose progressively in participants with HbA1c ≥6.5 percent to <7.0 percent (odds ratio [OR], 4.30; 95 percent CI, 1.11–16.65; p=0.035), ≥7.0 percent to <8.0 percent (OR, 4.48; 1.24–16.17; p=0.022) and ≥8.0 percent (OR, 7.65; 1.95–30.00; p=0.003).
The link between sarcopaenia and glycaemic control remained significant even when HbA1c was taken as a continuous variable in the model adjusted for only basic confounders (OR, 1.29; 1.01–1.74; p=0.041).