Most Read Articles
Tristan Manalac, 06 Nov 2018
Intravenous cefiderocol thrice daily is noninferior to imipenem-cilastatin for treating complicated urinary tract infection (UTI) patients with multidrug-resistant, Gram-negative infections, according to a recent study.
01 Nov 2018
Genotype 4 hepatitis E virus infection does not appear to be correlated with acute, nontraumatic neurologic disorders, according to a recent China study.
01 Nov 2018
In patients with genotype 3 hepatitis C virus (HCV) infection and decompensated cirrhosis, the rate of achieving sustained virologic response 12 weeks after treatment (SVR12) is high with treatment regimens consisting of sofosbuvir and velpatasvir with or without ribavirin, according to the results of a phase II trial. However, the rate appears to be lower in the subgroup of patients with baseline resistance-associated substitutions in nonstructural protein 5A.
07 Nov 2018
In infants with early-life acute respiratory infection (ARI) with respiratory syncytial virus (RSV), elevated nasopharyngeal Lactobacillus levels protect against wheezing illnesses at 2 years of age, a recent study has found.

Polyomaviruses, cytomegalovirus infection tied to childhood obesity

19 Oct 2018
Children born via caesarean-section have an increased risk in developing childhood obesity and this has been linked to the lack of exposure to a mother’s gut bacteria.

Seropositivity to polyomaviruses and cytomegalovirus (CMV) correlates with obesity in childhood, a recent study has shown.

Researchers recruited 687 children (52.4 percent male), in whom the presence of IgG antibodies to ten polyomaviruses and four herpesviruses was measured at age 4 years. Obesity traits, such as body mass index (BMI) standard deviation (SD) scores and skinfold thickness, were evaluated at age 4 and 6 years.

At the 4-year follow-up, the prevalence of overweight was 14.1 percent while that of obesity was 6.7 percent. The corresponding values at the 6-year follow-up was 21.8 percent and 9.6 percent. Children who were seropositive for the BKPyV polyomavirus were less likely to be obese at 4 years (49.6 percent vs 7.16 percent) and 6 years (12.27 percent vs 17.14 percent) than their seronegative counterparts.

The same was true for those who were seropositive for the KIPyV polyomavirus and the likelihood of obesity at 4 years (3.96 percent vs 8.85 percent). In comparison, those who were seropositive for CMV were more likely to be overweight at age 4 years (19.77 percent vs 12.16 percent).

Similar findings were obtained for obesity outcomes. Those who were seropositive for the BKPyV polyomavirus had significantly lower BMI SD scores at 4 years (β, –0.21; 95 percent CI, –0.39 to –0.03) and 6 years (β, –0.27; –0.48 to –0.05) of age. Trends were similar for waist circumference, body fat percentage and sum of skinfolds.

On the other hand, CMV-seropositive children had higher BMI SD scores at age 4 years (β, 0.28; 0.11–0.45) and 6 years (β, 0.24; 0.03–0.45), as well as the sum of skinfolds at 6 years (β, 4.75 mm; 0.67–8.83).

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Most Read Articles
Tristan Manalac, 06 Nov 2018
Intravenous cefiderocol thrice daily is noninferior to imipenem-cilastatin for treating complicated urinary tract infection (UTI) patients with multidrug-resistant, Gram-negative infections, according to a recent study.
01 Nov 2018
Genotype 4 hepatitis E virus infection does not appear to be correlated with acute, nontraumatic neurologic disorders, according to a recent China study.
01 Nov 2018
In patients with genotype 3 hepatitis C virus (HCV) infection and decompensated cirrhosis, the rate of achieving sustained virologic response 12 weeks after treatment (SVR12) is high with treatment regimens consisting of sofosbuvir and velpatasvir with or without ribavirin, according to the results of a phase II trial. However, the rate appears to be lower in the subgroup of patients with baseline resistance-associated substitutions in nonstructural protein 5A.
07 Nov 2018
In infants with early-life acute respiratory infection (ARI) with respiratory syncytial virus (RSV), elevated nasopharyngeal Lactobacillus levels protect against wheezing illnesses at 2 years of age, a recent study has found.