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Roshini Claire Anthony, 4 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 5 days ago
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Dr. Wong Soon Tee, 5 days ago
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Polygenic risk scores more predictive of early- than late-onset colorectal cancer

16 Apr 2020

Genetic variants associated with colorectal cancer (CRC) appear to strongly predict early-onset more than late-onset malignancies, a new study has shown.

Researchers calculated the weighted polygenic risk score (PRS) to assess the risk of developing CRC in 12,197 participants aged <50 years, and in 95,865 participants aged 50 years. Single nucleotide polymorphisms known to be associated with CRC were used for PRS calculation. Findings were replicated in a separate cohort of 72,573 participants.

Each standard deviation (SD) increase in PRS score was correlated with CRC risk, and more strongly in participants <50 years of age (pinteraction=0.01).

For example, the highest vs lowest quartile of PRS increased the risk of late-onset CRC by almost threefold (odds ratio [OR], 2.92, 95 percent confidence interval [CI], 2.80–3.04) while the risk almost quadrupled for early-onset CRC (OR, 3.73, 95 percent CI, 3.28–4.24).

This trend remained consistent even when stratifying according to family history. In those without first-degree exposures, high PRS was more strongly correlated with early-onset (OR, 4.26, 95 percent CI, 3.61–5.01) than late-onset (OR, 2.85, 95 percent CI, 2.70–3.00) CRC. The same was true for participants with first-degree exposures.

The findings were also replicated in the independent cohort. Overall, each SD increase in PRS had a stronger effect on CRC in those aged <50 years (hazard ratio [HR], 1.73, 95 percent CI, 1.17–2.56) than in their older counterparts (HR, 1.43, 95 percent CI, 1.34–1.51).

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Most Read Articles
Roshini Claire Anthony, 4 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 5 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
Yesterday
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 5 days ago
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.