Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

3 days ago
Waist circumference (WC) trajectories are predictive of altered risk of cardiovascular disease (CVD) among adults, even among those without body mass index (BMI)-defined obesity, a study has shown. Such association appears higher in younger adults.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Polygenic risk scores estimate keratinocyte cancer risk in organ transplant recipients

06 Feb 2021
An organ transplant surgery taken place with the “most well-respected manner,” reassures Dr Hirman. Photo credit: Dr Hasdy Haron, clinical manager at National Transplant Resource Centre, Malaysia.

A polygenic risk score (PRS) helps identify organ transplant recipients (OTRs) who are at high risk of developing keratinocyte cancers (KCs), which in turn could improve screening and preventive strategies, a new study has found.

Drawing from the UK Biobank and 23andMe databases, the researchers generated PRSs in nontransplantee individuals with squamous cell carcinoma (SCC; n=13,981), basal cell carcinoma (BCC; n=33,736), and controls (n>560,000). They then tested the predictive ability of the PRS in an independent OTR cohort.

From the derivation cohort, the researchers identified 142 and 31 single-nucleotide polymorphisms (SNPs) that could potentially provide the best predictive value for BCC (BCC142) and SCC (SCC31), respectively. Subsequent case-control analyses included 630 and 642 participants for the analysis of the respective PRSs.

After adjusting for traditional risk factors, the corresponding risk scores were found to be significantly associated with BCC (odds ratio [OR], 1.60, 95 percent confidence interval [CI], 1.24–2.05; p=2.6×10–4) and SCC (OR, 1.31, 95 percent CI, 1.03–1.65; p=0.028).

The researchers then divided patients according to PRS. ORs in the top 20 percent of BCC scores saw a 23-percent absolute risk of developing BCC. Those in the bottom 20 percent only had a risk estimate of 8.7 percent, not significantly higher than the 6.8-percent BCC prevalence among nontransplantees. OTRs in the top PRS category of BCC were more than thrice as likely to develop BCC than the bottom group (OR, 3.25, 95 percent CI, 1.44–7.31; p=4.4×10–3).

For SCC, absolute risks were 24.6 percent and 10.9 percent in the top and bottom 20 percent of PRSs, respectively, representing a more than twofold jump in likelihood (OR, 2.11, 95 percent CI, 0.98–4.53).

“OTRs in the highest genetic risk quintile could benefit from more intense KC screening and preventive strategies than their counterparts,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

3 days ago
Waist circumference (WC) trajectories are predictive of altered risk of cardiovascular disease (CVD) among adults, even among those without body mass index (BMI)-defined obesity, a study has shown. Such association appears higher in younger adults.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.