Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
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Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Stephen Padilla, 2 days ago
Use of systemic corticosteroids does not reduce in-hospital mortality for patients with severe or critical coronavirus disease (COVID-19), which is in stark contrast to that observed in the RECOVERY clinical trial, according to a study in Wuhan, China.

Pleuroparenchymal fibroelastosis tied to lower lung function, poorer prognosis in IPF patients

29 Sep 2020

Body mass index (BMI) and lung function are lower in patients with pleuroparenchymal fibroelastosis (PPFE) compared with those without, according to a study. The PPFE arm also has more frequent complications and poorer survival during follow-up.

The authors assessed the clinical significance of the radiologically defined PPFE in patients with idiopathic pulmonary fibrosis (IPF; mean age, 66.4 years; 76.4 percent male) by retrospectively analysing clinical data and chest CT images in 445 participants (biopsy-proven cases, n=165).

The radiological criteria of PPFE was defined as bilateral subpleural dense fibrosis with or without pleural thickening in the upper lobes, evidence of disease progression, and no clinical evidence of identifiable aetiologies.

Of the patients, 28 (6.3 percent) were identified to have PPFE. The median follow-up period was 43.0 months. Those with PPFE demonstrated lower BMI and lung function (ie, forced vital capacity and total lung capacity) at baseline, more frequent pneumothorax and pneumomediastinum, higher decline rates in lung function, and poorer prognosis during follow-up compared with patients without PPFE.

Notably, PPFE was independently associated with pneumothorax or pneumomediastinum (hazard ratio, 2.953, 95 percent confidence interval, 1.350–6.460; p=0.007), but not for mortality in patients with IPF.

“PPFE is characterized by fibrosis in the pleura and subpleural lung parenchyma in the upper lobes, while other types of interstitial lung disease, mainly usual interstitial pneumonia, can be observed in about half of the patients in their lower lobes,” the authors said.

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Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Stephen Padilla, 2 days ago
Use of systemic corticosteroids does not reduce in-hospital mortality for patients with severe or critical coronavirus disease (COVID-19), which is in stark contrast to that observed in the RECOVERY clinical trial, according to a study in Wuhan, China.