Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting. 

Platelet reactivity still high after clopidogrel therapy in symptomatic femoropopliteal disease

30 Mar 2020

Platelet reactivity remains high in patients with symptomatic femoropopliteal disease treated with clopidogrel vs ticagrelor after implantation of drug-eluting stents (DESs), a new study has found.

Researchers randomly assigned 40 eligible patients who had undergone DES implantation to receive ticagrelor (mean age, 73±9 years; 70 percent male) or clopidogrel (mean age, 71±9 years; 60 percent male) with aspirin for the first 3 months and alone for the succeeding 9 months. Platelet reactivity was the outcome of interest and was assessed before the intervention and at the 3-month follow-up, after aspirin discontinuation.

Mean platelet reactive units (PRUs) were significantly higher at 3 months in patients who had been treated with clopidogrel (200±61 vs 81±72; p<0.001). Baseline PRU values were comparable between groups (242±60 vs 261±60). The decrease from baseline in the ticagrelor arm was also significant (p<0.0001).

In contrast, frequency-domain optical coherence tomography (FD-OCT) showed that ticagrelor and clopidogrel were similarly effective in terms of percentage volume obstruction at follow-up (29.7±17.6 percent vs 31.2±10.7 percent; p=0.78).

Similarly, the percentage of uncovered stent struts was comparable between the treatment arms (24.2±32.8 percent vs 15.3±15.8 percent; p=0.4).

Both interventions also had comparable clinical efficacy. Target limb vascularization was reported in five patients in the ticagrelor group and in six in the clopidogrel arm. Three deaths were reported, two of which were from the clopidogrel group.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Pank Jit Sin, 14 Apr 2020
With the movement control order (MCO) in full gear, most conferences and meetings are being postponed or cancelled. Some have taken to having conferences and meetings in a virtual setting, such as the recently ended American College of Cardiology/World Congress of Cardiology (ACC.20/WCC) conference. MIMS and the Asian Young Pharmacist Group (AYPG) took this opportunity to engage with pharmacists in the form of a Zoom meeting.