Most Read Articles
Stephen Padilla, 4 days ago
Diabetic patients in a decompensated state and who develop type 2 myocardial infarction (MI) have an increased risk for mortality and major adverse cardiac events (MACE), according to a new study. In addition, these patients are potentially at risk for undiagnosed coronary artery disease.
6 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 13 Jul 2018
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
6 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.

Platelet count does not predict bleeding in cirrhotic patients

29 Mar 2018

In cirrhotic patients, platelet count does not appear to have significant predictive value for unprovoked major or minor bleeding, a recent study has shown.

Researchers recruited 280 consecutive cirrhotic patients (mean age 64±37 years; 188 males) in whom the severity of liver disease was assessed using the Child-Pugh and Model for End-Stage Liver Disease (MELD) scores. Cox proportional hazards analysis was performed to determine associations between outcomes and clinical variables.

Major bleeding events were reported in 34 patients (12 percent), most of whom (91 percent; n=31) had bleeding related to portal hypertension; the remaining cases were due to intracerebral and bronchial tree haemorrhage. Six patients died due to major bleeding.

MELD scores were significantly higher (13.3±5.7 vs 10.9±5.5; p=0.0215) and encephalopathy was significantly more frequent (41 percent vs 19.5 percent; p=0.017) in patients who experienced major bleeding.

Previous gastrointestinal bleeding (hazard ratio [HR], 2.40; p=0.012) and hepatic encephalopathy (HR, 2.47; p=0.010) were significant and independent predictors of major bleeding in the fully-adjusted models.

Only 18 patients showed minor bleeding over a median follow-up of 186 days, yielding an annual rate of 1.89 percent.

Between bleeders and nonbleeders, only the Child-Pugh (p=0.0461) and MELD (p=0.0193) scores, presence of encephalopathy (p=0.0071), previous gastrointestinal bleeding events (p=0.0117), serum albumin (p=0.0373) and prothrombin time-international normalized ratio (p=0.0029) were significantly different.

Platelet counts, the presence of ascites, age, sex, disease aetiology, serum levels of creatinine and bilirubin, and use of β-blockers and aldosterone receptor agonists were statistically comparable between the two patient groups.

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Most Read Articles
Stephen Padilla, 4 days ago
Diabetic patients in a decompensated state and who develop type 2 myocardial infarction (MI) have an increased risk for mortality and major adverse cardiac events (MACE), according to a new study. In addition, these patients are potentially at risk for undiagnosed coronary artery disease.
6 days ago
Chocolate consumption is not associated with risk of coronary heart disease (CHD), stroke or both combined in postmenopausal women free of pre-existing major chronic disease, a study suggests.
Pearl Toh, 13 Jul 2018
More intensive lowering of LDL-C levels was associated with a progressively greater survival benefit than less intensive approach, when the baseline LDL-C levels were ≥100 mg/dL, reveals a meta-analysis of 34 randomized trials.
6 days ago
Switching from thiazide diuretic to ipragliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, leads to improvements in metabolic parameters and body mass composition without affecting blood pressure in type 2 diabetes (T2D) patients, a recent study has found.