Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.

Plasma xanthine oxidoreductase tied to liver transaminase level in T2DM patients

01 Dec 2020

Among patients with type 2 diabetes mellitus (T2DM), plasma levels of xanthine oxidoreductase (XOR) share a close relationship with circulating levels of liver transaminases, a new study has found. This interaction suggests that XOR may find use as an indicator of liver damage in these patients.

The study included 28 T2DM patients (mean age, 63.4 years; 10 males) who were scheduled to undergo diabetes treatment. Triple quadrupole mass spectrometry and liquid chromatography were performed to measure plasma XOR activity. The outcome of interest was the interaction between changes in XOR and clinical parameters.

Unadjusted analyses revealed that plasma XOR was associated with factors such as body weight, body mass index (BMI), waist circumference, estimated glomerular filtration rate (eGFR), high-sensitivity C-reactive protein (hs-CRP), and liver enzyme, including aspartate (AST) and alanine (ALT) transaminase.

Over 2 weeks of hospitalization, participants lost a significant mean weight of 1.3 kg (p<0.0001), which coincided with similar improvements in clinical parameters, including plasma glucose, glycated haemoglobin, and hs-CRP.

At the same time, plasma XOR also slightly but significantly decreased (p=0.041). A trend in decreasing ALT and AST was also observed.

Stepwise multiple regression showed that change in the log of AST over 2 weeks of hospitalization was the only significant and independent correlate of the change in the log of plasma XOR activity (R, 0.82; p<0.0001).

“[T]he present results showed a close relationship between plasma XOR activity and circulating levels of liver transaminases in patients with T2DM, cross-sectionally and across hospitalized treatment, suggesting that plasma XOR reflects liver damage in patients with diabetes,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Yesterday
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.