Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.

Plasma viral load suggests worse COVID-19 outcomes

11 Nov 2020

A higher plasma viral load of SARS-CoV-2 is indicative of a more severe disease and worse survival outcomes, a recent study has shown. Viral load information may help in the risk stratification of patients with the novel coronavirus disease (COVID-19).

The study included 88 hospitalized COVID-19 patients (median age, 57 years; 38 percent female), 90 symptomatic patients who did not need admission (median age, 48 years; 62 percent female), and 53 patients who had symptomatically recovered from COVID-19 (median age, 33 years; 65 percent female). Viral load in plasma samples was measured using quantitative polymerase chain reaction.

More than a quarter (27 percent) of the hospitalized patients had detectable SARS-CoV-2 RNA in their plasma compared with only 13 percent of outpatients. Plasma viraemia was generally associated with worse COVID-19 severity among hospitalized participants: 44 percent of those hooked to a ventilator had detectable viremia as opposed to none of the patients who did not need supplemental oxygen.

Higher plasma viral load in hospitalized patients also correlated with markers of inflammation, including elevated C-reactive protein (p=0.0003) and interleukin (IL)-6 (p<0.0001), as well as lower absolute lymphocyte count (p=0.008).

Eleven deaths were reported in the study, all of which were caused by respiratory failure. Compared with patients who had survived to discharge, those who died showed significantly greater levels of plasma viraemia at the time of sampling (p=0.009). Initial detectable viraemia conferred a more than fivefold increase in the estimated risk of death (odds ratio, 5.5; p=0.02).

None of the samples from the 53 recovered participants had detectable levels of SARS-CoV-2 RNA.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
22 Nov 2020
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

4 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.
Pearl Toh, 2 days ago
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.