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Plasma glucagon consistently deregulated in T1D patients

11 Sep 2019

Type 1 diabetes (T1D) patients experience a consistent dysregulation of plasma glucagon levels, a new Japan study has found.

The study included 77 T1D patients (mean age, 34.9±6.4 years; 67.5 percent female) whose plasma glucagon levels were measured from venous blood samples using dual-antibody sandwich enzyme-linked immunosorbent assay. Upon enrolment, the mean disease duration was 25.8±7.7 years, while the mean plasma glucagon concentration was 16.0±9.8 pg/mL.

Over two annual check-ups, plasma glucagon was significantly correlated with plasma glucose (r, 0.265; p=0.02), blood urea nitrogen (r, 0.325; p=0.004), alanine aminotransferase (r, 0.253; p=0.03), total cholesterol (r, 0.234; p=0.04) and low-density lipoprotein cholesterol (r, 0.250; p=0.03).

No such relationships were documented for other clinical parameters tested, including glycated haemoglobin, creatinine, glycoalbumin, uric acid and gamma-glutamyltransferase, among others.

Subsequent multivariate logistic regression analysis found that of all the tested variables, only blood urea nitrogen was significantly correlated with blood glucagon (p=0.02).

Moreover, among those who had available data from two medical check-ups (n=66), plasma glucagon levels from the first visit were significantly correlated to measurements a year after (r, 0.407; p=0.007), though the mean concentration showed an overall decline (p<0.001).

“In the current study, we investigated the annual change in plasma glucagon levels in these same patients and found a significant correlation between measurements in both years,” said researchers, noting that glucagon similarly shared a significant relationship with BUN.

“These results suggest a potentially constant dysregulation of glucagon in association with altered amino acid metabolism in patients with T1D,” they added.

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Most Read Articles
12 Jan 2020
Testosterone treatment may slightly improve sexual functioning and quality of life in men without underlying organic causes of hypogonadism, but it offers little to no benefit for other common symptoms of ageing, according to a study. In addition, long-term efficacy and safety of this therapy remain unknown.
10 Feb 2020
Pregnant women with thyroiditis may do well with selenium supplementation, which confers benefits for autoantibody titre during pregnancy and thyroiditis recurrence postpartum, as shown in a study.
12 Nov 2019
Use of the feminizing hormone therapy medroxyprogesterone acetate (MPA) results in minimal side effects, unchanged oestradiol levels and a decline in testosterone in a cohort of transwomen, a study has found.