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Stephen Padilla, 6 days ago
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Plasma acylcarnitines tied to higher risk of T2D in people at high CV risk

10 Apr 2019

Plasma acylcarnitines, mainly including short- and long-chain acylcarnitines, are a predictor of type 2 diabetes (T2D) in individuals at high cardiovascular risk, according to a study.

Furthermore, including acylcarnitines into the model does not significantly improve T2D prediction C-statistics beyond traditional risk factors, including fasting glucose.

To examine the relationship between baseline and 1-year changes in acylcarnitines and their diabetes predictive ability beyond traditional risk factors, a case-cohort study was designed within the PREDIMED Study including all incident T2D cases (n=251) and randomly selected participants (n=694) at baseline (follow-up, 3.8 years).

A targeted approach by liquid chromatography–tandem mass spectrometry was used to measure plasma acylcarnitines. The investigators used weighted Cox regression models to test the associations between baseline and 1-year changes in individual acylcarnitines and T2D risk. They also used elastic net regressions to select acylcarnitines for T2D prediction and a cross-validation approach to compute a weighted score.

A significant association was found between an acylcarnitine profile and a higher risk of T2D independent of traditional risk factors. For every standard deviation (SD) increment of the predictive model scores, the relative risks of T2D were 4.03 (95 percent CI, 3.00–5.42; p<0.001) for the conventional model and 4.85 (3.65–6.45; p<0.001) for the model including acylcarnitines (hazard ratio attributed to acylcarnitines, 1.33; 1.08–1.63; p<0.001).

The inclusion of acylcarnitines into the model did not significantly improve the area under the receiver operator characteristic curve (0.86–0.88; p=0.61). Furthermore, an association existed between a 1-year increase in C4OH-carnitine and higher T2D risk (per SD increment, 1.44; 1.03–2.01).

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Most Read Articles
Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.
Yesterday
Systolic blood pressure appears to have a strong association with aneurysmal subarachnoid haemorrhage (aSAH) but not with unruptured intracranial aneurysm (UIA), whereas current smoking and female sex are risk factors for both conditions, a study has found.