Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.

Pitavastatin superior to other statins for preventing diabetes in AMI patients

08 Oct 2018

Moderate-intensity pitavastatin appears to lower the incidence rate of new-onset diabetes mellitus (NODM) in acute myocardial infarction (AMI) patients, a recent study reports.

Researchers enrolled 2,001 AMI patients without diabetes mellitus, of whom 1,267 received atorvastatin (mean age 64.4±12.5 years; 76.6 percent male), 960 received rosuvastatin (mean age 63.2±12.4 years; 76.1 percent male) and 255 were given pitavastatin (mean age 63.4±12.0 years; 72.2 percent male). The cumulative NODM incidence was evaluated across the different groups.

Kaplan-Meier curves showed that the 3-year cumulative incidence rate of NODM was significantly lower in the pitavastatin group than in the atorvastatin and rosuvastatin groups (3.0 percent vs 8.4 percent and 10.4 percent; p=0.001).

Multivariate Cox regression analysis further provided proof for this association, showing that the type of statin taken was an important prognostic factor for NODM. Those who received atorvastatin (hazard ratio [HR], 2.6; 95 percent CI, 1.163–5.879; p=0.0201) or rosuvastatin (HR, 3.9; 1.756–8.689; p=0.0008) were significantly more likely to develop NODM than those who were given pitavastatin.

Notably, atorvastatin was superior to rosuvastatin in terms of NODM prognosis (HR, 0.669; 0.456–0.982; p=0.0401).

Other significant risk factors included triglyceride (HR, 1.004; 1.003–1.006; p<0.0001) and glucose (HR, 1.006; 1.003-1.008; p<0.0001) levels.

“The present study is the first study that evaluated the effect of statin type on NODM incidence in patients with AMI and compared diabetogenic effect among different same intensity statin therapies,” said researchers.

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Most Read Articles
24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

26 Dec 2017
Supplementation with omega-3 fatty acids in combination with rosuvastatin may yield significant reductions in triglycerides and nonhigh-density lipoprotein (HDL) cholesterol as compared with rosuvastatin monotherapy, according to data from the ROMANTIC (rosuvastatin-omacor in residual hypertriglyceridemia) trial.
Teng Sung Shin, Joyce Lam Ching Mei, 03 Sep 2018
Bleeding disorders in children can be divided into acquired and congenital conditions, with the acquired being far more common than the congenital. Clinical bleeding manifestations can vary in severity. Identifying the root cause early is crucial to control and halt bleeding as well as to prevent the risk of future bleeding in a vulnerable age group. This can be achieved by a thorough and salient history, physical evaluation, and appropriate investigations. This review will describe the common causes of bleeding disorders in children and will suggest an approach to the workup and diagnosis of such disorders.
Rachel Soon, 12 Dec 2018

MIMS Pharmacist presents an overview of superoxide dismutase (SOD) and its role in resisting the effects of oxidative stress and aging.