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Physical activity confers benefits for T2DM therapy-related quality of life

13 Mar 2018

High levels of physical activity are associated with good therapy-related quality-of-life (QOL) scores among type 2 diabetes mellitus (T2DM) patients, a study suggests.

Researchers analysed cross-sectional data from 2,970 patients with T2DM (mean age 65.8 years; mean BMI, 24.7 kg/m2; mean HbA1c level, 7.6 percent [58.7 mmol/mol]) in a Japanese diabetes registry. They estimated correlations between diabetes therapy-related quality of life (DTR-QOL; domains 1–4) and physical activity levels using logistic regression.

In univariate models, physical activity levels were significantly associated with scores for DTR-QOL domains 1 (p=0.0046), 2 (p=0.0004) and 4 (p<0.001), but not domain 3 (p=0.5073).

In multivariable models, the association of high physical activity levels with DTR-QOL scores was seen for domains 1 (quartiles 2–4 vs quartile 1 of physical activity: odds ratios [ORs], 1.16, 1.56 and 1.22, respectively; p=0.032) 3 (ORs, 1.45, 1.55 and 1.38; p=0.049) and 4 (ORs, 1.09, 1.30 and 1.51; p=0.001), but not domain 2 (ORs, 1.19, 1.26 and 1.23; p=0.096).

Researchers noted that choosing diabetes therapy might be associated with attaining high QOL levels, with higher QOL leading to more physical activity, and more physical activity, in turn, resulting in preference to avoid medicines that increase likelihood of hypoglycaemia.

Treatment guidelines highlight the importance and effectiveness of including physical activity in T2DM therapeutic strategies. Nevertheless, adherence to long-term physical activity may be perceived as a burden, which could have a negative effect on health-related QOL despite improved clinical outcomes. [Diabetologia 2012;55:1577-1596]

It is thus important to identify factors associated with improved adherence to physical activity therapy, researchers said.

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Tee Hoi Poh, 26 Sep 2018
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