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21 Sep 2020
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Jairia Dela Cruz, 16 Sep 2020
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Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
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Phenobarbital safe, effective for alcohol withdrawal syndrome in psychiatric inpatients

09 Aug 2020

Use of phenobarbital is effective for the prevention and treatment of alcohol withdrawal syndrome (AWS) in psychiatric inpatients, a study has shown. Moreover, it is safe and neither leads to severe adverse effects nor requires a higher level of care.

The investigators conducted this single-centre, retrospective, observational study to describe the potential role of phenobarbital as therapy for the management of AWS among medically cleared psychiatric inpatients.

A total of 122 adult patients admitted to the psychiatric unit and administered phenobarbital were included in the analysis. Changes in vital signs and signs and symptoms of AWS were observed to evaluate the safety and efficacy of the study drug. Safety, the primary outcome, was measured by change in the respiratory rate (RR).

No significant changes in RR were observed among patients who received phenobarbital for the prevention and treatment of AWS. On the other hand, blood pressure and heart rate were significantly decreased.

Ninety-four percent of patients with documented signs and symptoms of AWS upon admission showed improvements during phenobarbital therapy. Nearly 12 percent of patients had documented sedation or altered mental status during treatment, but none required transfer to a medical or critical care unit.

In general medical patients, use of phenobarbital was also effective and safe, as shown by the results of a 2019 study by Nisavic and colleagues. Patients initiated on phenobarbital had similar outcomes to those on benzodiazepine treatment, which is the standard of care for the management of AWS. [Psychosomatics 2019;60:458-467]

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Most Read Articles
21 Sep 2020
Chest pain appears to be the principal complaint of patients hospitalized with a first myocardial infarction (MI), particularly among those in the youngest age group, a study has found.
Jairia Dela Cruz, 16 Sep 2020
In patients with heart failure with reduced ejection fraction (HFrEF) receiving angiotensin-converting-enzyme (ACE) inhibitors, high dosing confers benefits for the risk of death or hospitalization that are similar to that obtained with lower dosing, according to a systematic review and meta-analysis.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
2 days ago
Percutaneous coronary intervention (PCI), compared with coronary artery bypass grafting (CABG), in the revascularization of left main coronary artery (LMCA) disease may lead to death, myocardial infarction (MI), or stroke in patients with moderate or severe left ventricular (LV) dysfunction, reveals a study.