Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Phenelzine beneficial against recurrent castrate-sensitive prostate cancer

29 Apr 2020

The monoamine oxidase inhibitor phenelzine shows therapeutic potential in patients with biochemical recurrent castrate-sensitive prostate cancer, with manageable treatment-related toxicities, according to the results of a phase II trial.

Twenty patients (mean age, 66.9 years) with prostate-specific antigen (PSA) ≥0.4 ng/ml after prostatectomy or ≥2 ng/ml above nadir following radiation therapy (mean PSA, 4.7 ng/dl) received phenelzine 30 mg orally twice daily. None of them had evidence of metastasis on imaging.

A total of 244 cycles were administered, with the target dose of 60 mg/day achieved in 18 patients, five of whom were escalated to 90 mg/day. The median number of treatment cycles delivered per patient was 12.

PSA decreased from baseline by ≥30 percent in five patients (25 percent) and by ≥50 percent in two (10 percent). At week 12, 17 patients remained on treatment, with four exhibiting a PSA decline of ≥30 percent and one a decrease of ≥50 percent.

Commonly reported toxicities were dizziness (grade 1, 45 percent; grade 2, 35 percent), hypertension (grade ≥2, 30 percent) and oedema (grade 1, 25 percent; grade 2, 10 percent). One episode of grade 4 hypertension (at cycle 4) and two episodes of grade 3 syncope (at cycles 12 and 14) led to treatment discontinuation.

With respect to mood symptoms (evaluated using the hospital anxiety depression score questionnaire), treatment produced significant improvements in anxiety but no change in depressive symptoms.

The findings point to monoamine oxidase A as a potential new avenue for treatment in patients with recurrent prostate cancer, researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.