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Roshini Claire Anthony, 6 days ago

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Phenelzine beneficial against recurrent castrate-sensitive prostate cancer

29 Apr 2020

The monoamine oxidase inhibitor phenelzine shows therapeutic potential in patients with biochemical recurrent castrate-sensitive prostate cancer, with manageable treatment-related toxicities, according to the results of a phase II trial.

Twenty patients (mean age, 66.9 years) with prostate-specific antigen (PSA) ≥0.4 ng/ml after prostatectomy or ≥2 ng/ml above nadir following radiation therapy (mean PSA, 4.7 ng/dl) received phenelzine 30 mg orally twice daily. None of them had evidence of metastasis on imaging.

A total of 244 cycles were administered, with the target dose of 60 mg/day achieved in 18 patients, five of whom were escalated to 90 mg/day. The median number of treatment cycles delivered per patient was 12.

PSA decreased from baseline by ≥30 percent in five patients (25 percent) and by ≥50 percent in two (10 percent). At week 12, 17 patients remained on treatment, with four exhibiting a PSA decline of ≥30 percent and one a decrease of ≥50 percent.

Commonly reported toxicities were dizziness (grade 1, 45 percent; grade 2, 35 percent), hypertension (grade ≥2, 30 percent) and oedema (grade 1, 25 percent; grade 2, 10 percent). One episode of grade 4 hypertension (at cycle 4) and two episodes of grade 3 syncope (at cycles 12 and 14) led to treatment discontinuation.

With respect to mood symptoms (evaluated using the hospital anxiety depression score questionnaire), treatment produced significant improvements in anxiety but no change in depressive symptoms.

The findings point to monoamine oxidase A as a potential new avenue for treatment in patients with recurrent prostate cancer, researchers said.

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Most Read Articles
Roshini Claire Anthony, 6 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

Stephen Padilla, 28 May 2020
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.
3 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.