Most Read Articles
Elvira Manzano, 22 Jan 2018
A new study has shown an independent association between periodontal disease and incident stroke risk. What’s interesting is routine dental care can attenuate the stroke risk.
Audrey Abella, 17 Dec 2018
Low rates of cardiovascular (CV) or major bleeding complications were observed among octogenarians who were receiving active NOAC* therapy, suggesting that long-term anticoagulation with NOACs may result in a good risk-benefit ratio in this patient subgroup, according to data presented at ASH 2018.
Pank Jit Sin, 01 Feb 2019
Single pill combination (SPC) therapy is increasingly accepted and helps to overcome some of the problems associated with multipharmacy and compliance, says an expert. 
Rachel Soon, 31 Jan 2019

More home blood pressure (BP) and office BP measurements should be encouraged to identify otherwise hidden cases of hypertension, said an expert.

Pharmacoinvasive therapy, PPCI confer comparable survival benefits to transfer STEMI patients

11 Sep 2018

Pharmacoinvasive therapy (PIT) and primary percutaneous coronary intervention (PPCI) are comparable in terms of all-cause mortality in transfer patients with ST-elevation myocardial infarction (STEMI), a recent meta-analysis has shown.

Seventeen studies were eligible for inclusion in the meta-analysis, of which six were randomized controlled trials (RCTs) and 11 were cohort studies. Together, the studies corresponded to 13.037 patients who received either PPCI (n=7,398) or PIT (n=5,693). No evidence of small study effects or publication bias was reported.

Pooled analysis of the six RCTs showed PIT and PPCI were statistically comparable in terms of all-cause, short-term (odds ratio [OR], 0.99; 95 percent CI, 0.73–1.34; p=0.93) and long-term (OR, 0.83; 0.59–1.17; p=0.287) mortality. On the other hand, PPCI significantly increased the risk of all-cause, short-term mortality, according to the pooled analysis of observational studies (OR, 1.39; 1.04–1.87; p=0.028).

However, combining both RCTs and observational studies demonstrated that both approaches resulted in similar likelihood of all-cause short-term (OR, 1.20; 0.97–1.49; p=0.099) and long-term (OR, 1.17; 0.84–1.62; p=0.361) mortality.

The same was true for total stroke (OR, 0.76; 0.51–1.49; p=0.193), haemorrhagic stroke (OR, 0.56; 0.20–1.62; p=0.288), ischaemic stroke (OR, 0.65; 0.28–1.49; p=0.310) and major bleeding (OR, 0.73; 0.48–1.11; p=0.138).

In contrast, PPCI significantly increased the risk of cardiogenic shock (OR, 1.48; 1.13–1.94; p=0.005) and decreased the chances of reinfarction (OR, 0.69; 0.49–0.97; p=0.033) relative to PIT.

The databases of Embase, Scopus, PubMed and the Cochrane Library were accessed for the present meta-analysis. Studies on facilitated PCI and with ischaemia-guided reperfusion were excluded. The Newcastle-Ottawa scale was used to evaluate study quality.

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Most Read Articles
Elvira Manzano, 22 Jan 2018
A new study has shown an independent association between periodontal disease and incident stroke risk. What’s interesting is routine dental care can attenuate the stroke risk.
Audrey Abella, 17 Dec 2018
Low rates of cardiovascular (CV) or major bleeding complications were observed among octogenarians who were receiving active NOAC* therapy, suggesting that long-term anticoagulation with NOACs may result in a good risk-benefit ratio in this patient subgroup, according to data presented at ASH 2018.
Pank Jit Sin, 01 Feb 2019
Single pill combination (SPC) therapy is increasingly accepted and helps to overcome some of the problems associated with multipharmacy and compliance, says an expert. 
Rachel Soon, 31 Jan 2019

More home blood pressure (BP) and office BP measurements should be encouraged to identify otherwise hidden cases of hypertension, said an expert.