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Persistent wetting in childhood tied to urinary incontinence in adolescence

17 Mar 2017

Persistent wetting during childhood is associated with increased nocturia, bedwetting, daytime wetting, passing hard stools and urgency in adolescence, a new study finds.

The study included 8,751 (4,244 females) children with parent-reported bedwetting and daytime wetting frequency data for at least three of five timepoints: 4, 5, 6, 7 and 9 years of age. Information on bladder and bowel symptoms at age 14 were collected from the participants themselves.

Low stool frequency, passing hard stools, frequent urination, voiding postponement, low voided volume, nocturia, daytime wetting, urgency and bedwetting at age 14 were the primary outcomes of the study.  Parallel longitudinal latent class analysis (LLCA) was performed to create models for daytime wetting and bedwetting.

Five distinct, clinically relevant classes of urinary incontinence were established: normative development of bladder control (n=5,513; 47.5 percent male), delayed attainment of bladder control (n=752; 52.9 percent male), bedwetting alone (n=1,365; 68.4 percent male), daytime wetting alone (n=508; 33.5 percent male) and persistent wetting(n=613; 63.0 percent male).

Those in the daytime wetting alone (odds ratio [OR], 10.1; 95 percent CI, 4.50 to 10.8), persistent wetting (OR, 6.98; 4.50 to 10.8) and delayed bladder control (OR, 4.84; 3.11 to 7.54) classes had increased odds of daytime wetting at 14 years old.

There was an increased chance of bedwetting at 14 years in children that belonged to the persistent wetting (OR, 23.5; 15.1 to 36.5), bedwetting alone (OR, 3.69; 2.21 to 6.17) and delayed bladder control (OR, 3.83; 2.10 to 6.99) groups.

There was also a greater chance of nocturia and urgency in the persistent wetting class (OR, 2.39; 1.79 to 3.20; OR, 2.10; 1.44 to 3.07, respectively). Those in the daytime wetting alone (OR, 2.17; 1.27 to 3.71) and persistent wetting (OR, 2.64; 1.63 to 4.27) classes had greater odds of passing hard stools in adolescence.

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