Most Read Articles
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elaine Soliven, 4 days ago
Ultra rapid lispro (URLi) was noninferior to lispro in reducing HbA1c levels in adults with type 1 diabetes (T1D), according to the PRONTO-Pump-2* study presented at EASD 2020.

Persistent hyperglycaemia in preemies may alter body composition, neurodevelopment

30 Jul 2020
Premature babies are prone to birth-related complications, with effects running well into their lives if they do not first succumb to death.

In premature infants, prolonged hyperglycaemia may lead to lower fat mass and worse neurodevelopmental outcomes in the long run, a recent study has found.

Researchers accessed prospective data from 97 premature infants (born <32 weeks of gestation, 51.5 percent male). Hyperglycaemia was defined as blood glucose >150 mg/dL. The outcome of body composition was measured at 4 months’ postmenstrual age (PMA), while neurodevelopmental outcomes were assessed at 12 months’ PMA.

Almost half of the participants (48.5 percent) experienced hyperglycaemia; 27 percent had it for 1–4 days, and 21 percent experienced prolonged hyperglycaemia lasting for ≥5 days. Eighty-three infants had their body compositions measured between 32 and 42 weeks’ PMA, while 76 underwent the same measurement at 4 months’ PMA.

The Bayley Scales of Infant Development III (BSID-III) was used for the assessment of neurodevelopment, and at 12 months’ PMA was administered to 66 participants.

Prolonged hyperglycaemia showed a significant but inverse correlation with the z-scores for fat mass (p=0.007) and fat-free mass (p=0.003) at discharge, but only fat-free mass remained significant at 4 months’ PMA. However, adjusting for first-week nutrient intake attenuated all interactions.

Similarly, hyperglycaemia for ≥5 days was inversely correlated with BSID-III scores in the domain of cognition (p<0.02), language (p<0.02), and motor (p<0.01). Accounting for first-week nutrient intake again diminished these associations.

“These relationships appear to be mediated by decreased nutrient intake during the first week of life rather than the severity of illness,” researchers said. “Randomized trials of insulin therapy combined with nutritional adjustments are needed to determine the optimal strategy to improve long-term growth and neurodevelopmental outcomes.”

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Most Read Articles
Stephen Padilla, 22 Jul 2019
Zinc supplementation significantly lowers key glycaemic indicators, particularly fasting glucose (FG) in individuals with diabetes and in those who received an inorganic supplement, results of a systematic review and meta-analysis have shown.
Elaine Soliven, 15 Oct 2020

Higher levels of exercise appear to be associated with a lower risk of all-cause mortality in adults with type 2 diabetes (T2D) compared with no exercise at all, according to a study presented at EASD 2020.

Elvira Manzano, 07 Oct 2020
Exendin-4 imaging targeting GLP-1* receptor (GLP-1R) ably detects residual, dysfunctional pancreatic beta cells in individuals with long-standing type 1 diabetes (T1D), according to a study presented at EASD 2020. This breakthrough brings research closer to the possibility of restoring insulin-producing cells depleted in T1D.
Elaine Soliven, 4 days ago
Ultra rapid lispro (URLi) was noninferior to lispro in reducing HbA1c levels in adults with type 1 diabetes (T1D), according to the PRONTO-Pump-2* study presented at EASD 2020.