Most Read Articles
Roshini Claire Anthony, 3 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
2 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.

Persistent airway inflammation common in asthmatics despite medication use

11 Jan 2019

Airway type 2 inflammation remains persistent in many asthmatics on inhaled corticosteroids (ICS), a new study has shown. These patients tend to be older and have a more severe disease.

Using quantitative polymerase chain reaction, researchers measured expression levels of interleukins (IL) 4, 5 and 13 induced sputum samples collected from 259 asthmatic adults on ICS medication. Thirty healthy adults (mean age 38.0±13.1 years; 60 percent female) were also included as controls.

Expression levels of IL-4, IL-5 and IL-13 cytokines were significantly elevated in asthmatics than in healthy controls. The same was true for the type 2 gene mean (T2GM), which was the average gene expression of all three cytokines and functioned as a composite metric of airway type-2 gene expression.

Triamcinolone injection produced no significant effect on the expression levels of IL-4, IL-5 and IL-13. The resulting change in the T2GM was minimal, decreasing only by an average of 3 percent and not achieving statistical significance (p=0.19).

Using the 50th centile of T2GM values as a cutoff, researchers identified 130 asthmatics (74 percent female) with refractory type 2 inflammation despite ICS treatment. The remaining 129 (63 percent female) were designated as steroid-treated. Those in the former vs latter group tended to be older (mean, 50.3±14.0 vs 46.2±13.7 years; p=0.02).

The interaction between age and T2GM was further confirmed in a subsequent analysis where researchers divided the asthmatic participants into age quintiles. They found that T2GM values were significantly higher in older vs younger age quintiles.

Disease severity also appeared to play an important role in persistent inflammation. Those with high T2GM values had lower forced expiratory volume in 1 second values (69.5±17.9 percent vs 76.1±19.2 percent; p<0.001) and were more likely to be diagnosed with severe asthma (74 percent vs 62 percent).

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Most Read Articles
Roshini Claire Anthony, 3 days ago

Individuals with moderate-to-severe plaque psoriasis may reap better long-term improvements in the severity of their condition when treated with guselkumab over secukinumab, according to findings of the phase III ECLIPSE* trial presented at the recent Inflammatory Skin Disease Summit (ISDS 2018) held in Vienna, Austria.

Jairia Dela Cruz, 11 Jan 2019
Use of standard-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) appears to confer protection against the risk of endometrial cancer in overweight and obese women, according to a meta-analysis.
04 Jan 2019
Obstructive sleep apnoea may increase the risk of male-pattern baldness in men with a family history of hair loss, and this association appears to be mediated by low serum transferrin saturation levels related to hypoxia, a study suggests.
2 days ago
Discontinuing the use of tyrosine kinase inhibitors (TKIs) in the treatment of patients with chronic myeloid leukaemia appears to be feasible in real-life clinical practice in the context of close molecular monitoring, a study reports.