Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 2 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

5 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Audrey Abella, 07 Aug 2018
The use of the investigational first-in-class attachment inhibitor fostemsavir led to improved baseline viral and CD4+ T-cell counts in patients with HIV-1 infection who had limited treatment options and were failing their current antiretroviral regimen, according to the subgroup analysis results of the BRIGHTE* study presented at AIDS 2018.

Periodontitis ups risk of nonalcoholic fatty liver disease

01 Jun 2018
Roughly one in three adults suffer from the gum disease worldwide

Periodontal conditions, such as a probing pocket depth (PPD) ≥4 mm, appears to be a risk factor for ultrasound-diagnosed nonalcoholic fatty liver disease (NAFLD), a recent Japan study has shown.

Multivariate logistic regression showed that periodontitis, characterized as PPD 4 mm, was significantly associated with the prevalence of NAFLD (odds ratio [OR], 1.881; 95 percent CI, 1.184–2.987; p=0.007). Age showed a similar trend (OR, 1.024; 1.005–1.044; p=0.014).

Other significant risk factors included diastolic blood pressure (OR, 1.050; 1.020–1.080; p=0.001), C-reactive protein levels (OR, 3.208; 1.625–6.330; p=0.001), low-density lipoprotein (OR, 1.040; 1.010–1.072; p=0.008), body mass index (OR, 1.470; 1.373–1.575; p<0.001), triglycerides (OR, 1.011; 1.006–1.017; p<0.001) and total cholesterol (OR, 0.968; 0.943–0.994; p=0.017).

Subgroup analysis by sex showed that the significant relationship of periodontitis with NAFLD prevalence was retained in females (PPD ≥4 mm: OR, 2.972; 1.107–7.979; p=0.031) but was attenuated in males (OR, 1.620; 0.945–2.777; p=0.080).

Moreover, researchers showed that periodontitis was significantly more common in patients with vs without NAFLD (86.7 percent vs 72.9 percent; p<0.001).

Overall, the findings suggest “that the presence of periodontal disease may increase the risk of NAFLD,” said researchers.

“The present and previous studies indicate the importance of periodontal examination in order to assess the risk of metabolic diseases in the health-check population,” they added.

Researchers conducted a cross-sectional study on 1,226 adults (median age 50 years; 63.0 percent male), of whom 887 had NAFLD and 339 had no NAFLD. Periodontal probes at six sites were used to measure PPD, while ultrasonography was used to detect NAFLD.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Hepatology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 07 Aug 2018
A home-based, self-applied wearable electrocardiogram (ECG) patch facilitates diagnosis of atrial fibrillation (AF) among high-risk individuals, according to the mSToPS* trial.
Roshini Claire Anthony, 2 days ago

A genotype-guided approach to warfarin dosing may result in fewer dose adjustments in Asian patients, according to a study from Singapore.

5 days ago

Fungal microbiome, also called the mycobiome, appears to be highly variable in patients with well-characterized fungal diseases, a recent study has shown. Moreover, severe asthmatics have the highest fungal loads, along with those receiving steroid and antifungal therapy.

Audrey Abella, 07 Aug 2018
The use of the investigational first-in-class attachment inhibitor fostemsavir led to improved baseline viral and CD4+ T-cell counts in patients with HIV-1 infection who had limited treatment options and were failing their current antiretroviral regimen, according to the subgroup analysis results of the BRIGHTE* study presented at AIDS 2018.