Most Read Articles
Tristan Manalac, 5 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
3 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.

Periodontitis tied to nonalcoholic fatty liver disease

17 Dec 2017

Periodontitis is associated with nonalcoholic fatty liver disease (NAFLD), a recent epidemiological study has shown, adding that the presence of significant liver fibrosis makes this association more robust.

In the first part of the study, where researchers retrieved data from a population-based survey, findings showed that antibodies to the bacterial species Streptococcus noxia and S. oralis were strongly associated with the presence of steatosis even after adjusting for metabolic syndrome (odds ratios, 1.13 and 1.14, respectively).

Moreover, periodontal disease was found to be more severe in patients with advanced NAFLD, with those having high-risk NAFLD fibrosis scores (NFS) presenting with more clinical attachment loss (CAL) than those with low-risk scores.

In a subsequent patient-based study, where 69 NAFLD patients underwent dental examination, researchers found 12 periodontitis cases, resulting in a prevalence rate of 17.4 percent. Diabetes was significantly more frequent in the periodontitis patients (p=0.021).

Periodontitis patients were also significantly more likely to have nonalcoholic steatohepatitis (NASH) of any stage (p=0.0085) and NASH with fibrosis stages F2 to 4 (p=0.005) than those without periodontitis.

Periodontitis was also significantly associated with the stage of liver disease (NASH vs NFLD, p=0.008) and diabetes (p=0.01). Anthropometric and demographic factors such as age, body mass index, waist circumference, blood pressure, ethnicity, sex, and smoking status were unrelated to periodontitis.

“Epidemiological and clinical data reported here independently show a link between periodontitis and NAFLD, and this link is explained by features of metabolic syndrome including diabetes,” said researchers.

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Most Read Articles
Tristan Manalac, 5 days ago
The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
Pearl Toh, 4 days ago
Low-density lipoprotein cholesterol (LDL-C) levels remained high in many patients with stable or acute coronary heart disease (CHD) in Asia, despite having a very high risk of recurrent cardiovascular (CV) events, indicating that the use of lipid-lowering therapies and lipid monitoring were inadequate.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.
3 days ago
There is a strong association between smoking duration and colorectal polyps, independent of smoking intensity, cessation and other potential confounders, reports a recent study. Such association is more robust with distal rather than proximal polyps, and with serrated polyps rather than adenomas.