Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.

Periodontitis tied to nonalcoholic fatty liver disease

17 Dec 2017

Periodontitis is associated with nonalcoholic fatty liver disease (NAFLD), a recent epidemiological study has shown, adding that the presence of significant liver fibrosis makes this association more robust.

In the first part of the study, where researchers retrieved data from a population-based survey, findings showed that antibodies to the bacterial species Streptococcus noxia and S. oralis were strongly associated with the presence of steatosis even after adjusting for metabolic syndrome (odds ratios, 1.13 and 1.14, respectively).

Moreover, periodontal disease was found to be more severe in patients with advanced NAFLD, with those having high-risk NAFLD fibrosis scores (NFS) presenting with more clinical attachment loss (CAL) than those with low-risk scores.

In a subsequent patient-based study, where 69 NAFLD patients underwent dental examination, researchers found 12 periodontitis cases, resulting in a prevalence rate of 17.4 percent. Diabetes was significantly more frequent in the periodontitis patients (p=0.021).

Periodontitis patients were also significantly more likely to have nonalcoholic steatohepatitis (NASH) of any stage (p=0.0085) and NASH with fibrosis stages F2 to 4 (p=0.005) than those without periodontitis.

Periodontitis was also significantly associated with the stage of liver disease (NASH vs NFLD, p=0.008) and diabetes (p=0.01). Anthropometric and demographic factors such as age, body mass index, waist circumference, blood pressure, ethnicity, sex, and smoking status were unrelated to periodontitis.

“Epidemiological and clinical data reported here independently show a link between periodontitis and NAFLD, and this link is explained by features of metabolic syndrome including diabetes,” said researchers.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
6 days ago
Percutaneous coronary intervention (PCI) is a safe procedure to perform on obese and morbidly obese patients, a recent study has shown.
Roshini Claire Anthony, 11 Jun 2018

Patients who received a combination of ticagrelor plus aspirin within 24 hours of undergoing coronary artery bypass grafting (CABG) had significantly improved saphenous vein graft patency rates 1 year post-procedure compared with those who only received aspirin, according to findings of the DACAB* trial.

3 days ago
Higher activity of plasma xanthine oxidase appears to be linked to insulin resistance and liver dysfunction among type 2 diabetes mellitus (T2DM) patients with metabolic syndrome (MetS), according to a recent Japan study.
Pearl Toh, 3 days ago
Drinking more water did not significantly slow down the decline in kidney function of patients with stage 3 chronic kidney disease (CKD) at 1 year compared with patients who maintained their daily water intake, the CKD WIT* randomized study suggests.