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Dr. Melvin Wu, 01 Dec 2013

GPs can be crucial to identifying and helping codeine addicts get professional help to kick their habit.

Elvira Manzano, 01 Dec 2013

Neurogenesis, the birth of neurons or nerve cells in the hippocampus, continues during adulthood, new research suggests.

24 Aug 2016

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Dr. Andrea Luk, Dr. Doris Chan, 13 Sep 2016

A 40-year-old woman who underwent recent resection of a nonfunctional pituitary macroadenoma and radiotherapy to the pituitary gland complained of excessive thirst, polydipsia and polyuria.

Perfusion predict time to progression in glioblastoma

01 Aug 2017

Positive perfusion in surgical cavity wall enhancement (SCWE) may predict longer time to progression (TTP) in glioblastoma patients, a new study suggests.

The study included 60 glioblastoma patients receiving standard concurrent chemoradiation therapy (CCRT) after surgery. Exclusion criteria included magnetic resonance (MR) imaging performed more than 1 month after CCRT, no follow-up MR imaging and poor quality of arterial spin labelling (ASL) imaging.

Two readers independently assessed the SCWE for perfusions (positive or negative), contrast-enhancing lesions (presence or absence) and contrast enhancement pattern (nodular or non-nodular). Perfusion fraction was calculated by dividing areas of high perfusion by areas of contrast enhancement.

Univariate analysis showed that positive perfusion was significantly associated with longer TTP (hazard ratio [HR], 0.49; 95 percent CI, 0.25 to 0.96; p=0.04). Perfusion fraction with a higher volume was also associated with longer TTP for both reader 1 (HR, 0.98; 0.98 to 0.99; p=0.021) and 2 (HR, 0.98; 0.98 to 0.99; p=0.005).

Subsequent multivariable analysis showed that positive perfusion (HR, 0.33; 0.15 to 0.68; p=0.02) and a high perfusion fraction (HR, 0.97; 0.97 to 0.99; p=0.001 for reader 1 and HR, 0.98; 0.97 to 0.99; p<0.001 for reader 2) were both significant independent predictors of longer TTP.

Kaplan-Meier analysis showed that those with increased perfusion had significantly longer median TTP compared with those with decreased perfusion (29 vs 13 months; p=0.036).

Moreover, linear regression showed that perfusion fraction was significantly correlated with TTP for both readers (p<0.001 for both).

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Most Read Articles
Dr. Melvin Wu, 01 Dec 2013

GPs can be crucial to identifying and helping codeine addicts get professional help to kick their habit.

Elvira Manzano, 01 Dec 2013

Neurogenesis, the birth of neurons or nerve cells in the hippocampus, continues during adulthood, new research suggests.

24 Aug 2016

Roshini Claire Anthony spoke with Adjunct Associate Professor Gamaliel Tan, head and senior orthopaedic consultant at Ng Teng Fong Hospital in Singapore, on how GPs can help diagnose and treat lower back pain.

Dr. Andrea Luk, Dr. Doris Chan, 13 Sep 2016

A 40-year-old woman who underwent recent resection of a nonfunctional pituitary macroadenoma and radiotherapy to the pituitary gland complained of excessive thirst, polydipsia and polyuria.