Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Percutaneous endoscopic gastrostomy safe for patients in need of nutritional support

03 Oct 2019
The placement of percutaneous endoscopic gastrostomy (PEG) is a safe procedure, a recent study has found.

The study included 950 patients (mean age, 72.7±16.0 years; 52.9 percent female) who underwent PEG insertion or replacement. Medical records were accessed for the retrieval of information regarding patient characteristics, ongoing therapies, indications and comorbidities. Study outcomes included early and late complications, as well as mortality related to the procedure.

First PEG placement was performed in 62.5 percent (n=594) of the patients, most commonly for dysphagia due to stroke (33.0 percent). Elective placement dominated the procedures (96.3 percent), and placement was completed in 95.4 percent of cases.

The overall complication rate was only 4.8 percent. The most common complication was infection, accounting for half of all events. This was followed by bleeding (32.1 percent), dislodgement of the tube (14.3 percent) and buried bumper syndrome (3.6 percent). Infections occurred independently of antibiotic therapy (p=0.5).

The mortality rate in the PEG placement group was 5.2 percent, though all deaths were deemed unrelated to the procedure and its complications.

The remaining 37.5 percent (n=356) of patients underwent PEG replacement. The 30-day mortality rate in this group was 1.8 percent, and all were similarly not due to the operation. Only six PEG replacement patients reported complications, half of whom experienced tube dislodgement. One patient had bleeding.

Future studies are needed to determine the organizational and clinical factors associated with safety concerns regarding PEG placement and replacement, said researchers. These efforts will help improve care for patients undergoing these procedures.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.