Perceived stress, GI symptom anxiety predict HRQOL in IBS patients
Gastrointestinal (GI) symptom severity and anxiety are associated with the physical component score (PCS), while psychosocial and somatic measures correlate with the mental component score in irritable bowel syndrome (IBS), reports a recent study. Health-related quality of life (HRQOL), however, is similar in IBS patients and healthy controls when perceived stress, somatic symptom severity and mindfulness are at optimal levels.
Mean HRQOL was higher in 417 healthy controls compared with 290 IBS patients (PCS: 55.6 vs 48.6; p<0.001; MCS: 53.7 vs 44.8; p<0.001). In IBS patients, a negative association was seen between GI symptom measures and PCS; only usual severity correlated with MCS (p<0.01).
In all patients, “psychosocial and somatic measures correlated with MCS and not PCS excluding GI symptom anxiety, which correlated with both (p<0.01),” according to the authors.
Perceived stress in IBS and depression symptoms in HCs were the strongest predictors of MCS. The strongest predictor of PCS was GI symptom anxiety in both cohorts. Furthermore, greater perceived stress and somatic symptom, as well as less mindfulness, were associated with greater decreases in HRQOL for IBS vs healthy controls (p<0.01).
“These findings may have important implications in the management of IBS,” the authors said.
This study included IBS patients and healthy controls who completed validated questionnaires that measured GI symptoms, psychosocial/somatic variables, and physical (PCS) and mean (MCS) HRQOL via the Short-Form-36. The authors examined the associations between these variables and HRQOL using multiple linear regressions. Variables were standardized to determine the strongest predictors of HRQOL. Statistical significance level was 0.01.