Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.

Per-pregnancy assessment of hypertensive disorder miscalculates number of affected women

15 May 2020

The population-based incidence of hypertensive disorders of pregnancy (HDP) expressed as per-pregnancy underestimates the number of affected women during their reproductive years, according to a study. HDP history significantly increases the risks for future chronic conditions and multimorbidity.

A total of 9,862 pregnancies were identified, of which 719 (7.3 percent) had HDP and 324 (3.3 percent) had pre-eclampsia. Assessment on a per-woman basis doubled the incidence of HDP (281 of 1,839; 15.3 percent) and pre-eclampsia (138 of 1,839; 7.5 percent).

A history of HDP was significantly associated with a higher risk for subsequent diagnoses of stroke (hazard ratio [HR], 2.27, 95 percent confidence interval [CI], 1.37–3.76), coronary artery disease (HR, 1.89, 95 percent CI, 1.26–2.82), cardiac arrhythmias (HR, 1.62, 95 percent CI, 1.28–2.05), chronic kidney disease (HR, 2.41, 95 percent CI, 1.54–3.78) and multimorbidity (HR, 1.25, 95 percent CI, 1.15–1.35).

In this study, the authors used the Rochester Epidemiology Project medical record-linkage system to identify residents of Olmsted County, Minnesota, who gave birth between 1976 and 1982. Using a validated electronic algorithm, pregnancies were then classified into normotensive, gestational hypertension, pre-eclampsia, eclampsia, pre-eclampsia superimposed on chronic hypertension, and chronic hypertension.

The incidence of HDP was calculated both on a per-pregnancy and a per-woman basis. A Cox model was used to estimate HRs and corresponding 95 percent CIs in quantifying the risk of chronic conditions between women with and without a history of HDP (age and parity 1:2 matched).

“HDPs are associated with increased risks for cardiovascular disease later in life,” the authors said. “The HDP incidence is commonly assessed using diagnostic codes, which are not reliable and typically are expressed per-pregnancy.”

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Most Read Articles
29 Mar 2020
Targeting a low-density lipoprotein cholesterol level <70 mg/dL following an ischaemic stroke of atherosclerotic origin helps to avoid one in four subsequent major vascular events without increasing the risk of intracranial haemorrhage over about 5 years of follow-up, according to data from the Treat Stroke to Target trial.
Pearl Toh, 12 Sep 2020
Early initiation of rhythm-control therapy led to a significantly reduced risk of major adverse cardiovascular (CV) outcomes compared with usual care (typically rate control) in patients with newly diagnosed atrial fibrillation (AF) at risk of stroke, reveals the EAST-AFNET 4* trial presented at ESC 2020.
Audrey Abella, 16 Sep 2020
The final results of EVAPORATE* reinforce the plaque-regressing potential of icosapent ethyl (IPE) in patients on statins for elevated triglycerides.
01 Feb 2020
High-intensity statin therapy appears to be seeing increased use in patients with acute coronary syndrome and leads to better lipid control, according to a recent Thailand study.