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Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.

Pentraxin-3 linked to pre-eclampsia, HELLP syndrome

26 Sep 2020

Plasma levels of pentraxin-3 (PTX3) are linked to pre-eclampsia and the HELLP* syndrome, reports a recent study.

Researchers performed a case-control study of women with pre-eclampsia (n=368) and both pre-eclampsia and HELLP syndrome (n=195), using a quantitative enzyme immunoassay to measure plasma levels of PTX3. Readings were compared with that of women with healthy pregnancies at term (n=461), who were designated as controls.

Through multinomial logistic regression analysis, researchers found a significant log-linear interaction between PTX3 and the risk of both pre-eclampsia and HELLP syndrome. Each unit increase in PTX3, for instance, led to a 6-percent jump in the likelihood of pre-eclampsia (odds ratio [OR], 1.06, 96 percent confidence interval [CI], 1.03–1.10; p<0.001).

The effect was stronger for HELLP syndrome risk, which saw a 13-percent increase for each unit increment in PTX3 (OR, 1.13, 95 percent CI, 1.08–1.18; p<0.001).

Maternal and gestational age were found to be the strongest confounders of these interactions, and the risk estimates remained significant even after controlling for them. Multiple pregnancies, body mass index, socioeconomic status, and smoking were also confounders.

The researchers also saw that PTX3 levels remained a significant factor for pre-eclampsia and HELLP syndrome regardless of their time of onset.

“Further longitudinal studies and Mendelian randomization analyses would bring more insight into the role of PTX3 in pre-eclampsia,” they said.

*Haemolysis, elevated liver enzymes, and low platelet count.

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Most Read Articles
01 Sep 2020
Acute diarrhoea is the second leading cause of deathin children aged younger than 5 years, accounting forapproximately 1.9 million deaths worldwide each year;however, diarrhoea is a preventable and treatable condition.In Malaysia, acute gastroenteritis accounts for about 1.3%of all deaths in children aged younger than 5 years annually.Diarrhoea is defined as the passage of three or more looseor watery stools within 24 hours, and it may be clinicallycategorised as either acute watery diarrhoea (AWD), acutebloody diarrhoea, persistent diarrhoea or diarrhoea withsevere malnutrition.