Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Pembrolizumab–vorinostat combo shows antitumour activity in advanced/metastatic NSCLC

24 Dec 2019

In the treatment of patients with advanced/metastatic nonsmall cell lung cancer (NSCLC), the combination of pembrolizumab plus vorinostat has a tolerable safety profile and demonstrates preliminary antitumour activity despite progression on prior immune checkpoint inhibitor (ICI) therapy, according to the results of a phase I/Ib trial.

Thirty-three patients received intravenous pembrolizumab (200 mg every 3 weeks) plus oral vorinostat (200 or 400 mg/day). Phase I (open-label dose escalation; n=13) involved both ICI-naïve and ICI-pretreated patients, whereas phase Ib (dose expansion; n=20) included only those who had received prior ICI therapy.

There were no dose-limiting toxicities (DLT) recorded. The recommended phase I dose was 200 mg for pembrolizumab and 400 mg for vorinostat. Fatigue (33 percent) and nausea/vomiting (27 percent) were the most common any-grade adverse events.

Response was evaluable in six ICI-naïve and 24 ICI-pretreated patients overall. In the treatment-naïve cohort, there was one confirmed partial response (PR), four cases of stable disease (SD) and one case of progressive disease (PD). Disease control rate (DCR) was 83 percent. Median progression free survival (PFS) and overall survival (OS) were 7.5 months and 16.0 months, respectively.

In the ICI-pretreated cohort, three patients (one confirmed, two unconfirmed) had PR, 11 (46 percent) had SD and 10 (42 percent) had PD, for a DCR of 58 percent. Pretreatment CD8+ T-cell presence in tumour stromal regions was associated with treatment benefit.

The respective median PFS and OS were 4.6 months and 7.3 months in the ICI-relapsed NSCLC subgroup (n=11), and 2.8 months and 6.8 months in the ICI-refractory NSCLC group (n=13).

Researchers noted that the ongoing randomized phase II study will examine whether pembrolizumab plus vorinostat improves RR and PFS compared with pembrolizumab alone in ICI-naïve advanced/metastatic NSCLC patients.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.