Most Read Articles
Rachel Soon, 5 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.

PDE5i alone or in combination with SSRI better than SSRI monotherapy for premature ejaculation

03 May 2019

It appears that use of phosphodiesterase type 5 inhibitors (PDE5i) alone or in combination with serotonin reuptake inhibitors (SSRIs) is more effective than SSRIs alone in patients with premature ejaculation (PE), according to the results of a network meta-analysis.

“Nevertheless, it also has a problem about the side effects of PDE5i including gastrointestinal or central nervous systems complications, which prevents it as the first-line treatment drug,” the authors noted.

Twenty-five studies met the eligibility criteria in this network meta-analysis. PE oral drugs involved in the studies primarily included SSRIs and PDE5i. Results showed that these oral drugs have varying efficacies for the treatment of PE.

In terms of intravaginal ejaculation latency time at 4–6 weeks, the cumulative rank probability from best to worst was as follows: SSRIs + PDE5i, PDE5i alone, and other SSRIs alone. This meta-analysis also revealed that fluoxetine 20 mg, dapoxetine 60 mg, PDE5i, and SSRIs + PDE5i had a higher incidence rate (IR) of clinically relevant complications. On the other hand, SSRIs alone had relative lower IR.

“Despite the development of some promising new therapeutic options, SSRIs remained as the first line of therapeutic PE oral drug through a synthetical consideration at present,” the authors said.

To compare the effectiveness of oral drugs and several relevant complications in patients with PE, the following databases were comprehensively searched up to 1 May 2018: PubMed, Embase and Web of Science. The safety and efficacy of oral drugs in PE were evaluated by using the pooled standard mean difference or odds ratios with 95 percent credible interval.

Editor's Recommendations
Most Read Articles
Rachel Soon, 5 days ago

On 8 August, the first town hall held by the Ministry of Health (MOH) with members of the pharmacy profession took place in Putrajaya. Over 500 pharmacists from across the country and from different areas of practice—community and hospital, public and private, academy and industry—converged to fill the auditorium for the chance to engage in direct dialogue with MOH.

Stephen Padilla, 6 days ago
Early administration of recombinant human B-type natriuretic peptide (rhBNP) can lower the incidence of reperfusion injury for patients with ST-elevation myocardial infarction (STEMI) who are receiving percutaneous coronary intervention (PCI) treatment, according to a China study.
11 Aug 2019
Intraoperative methylprednisolone does not appear to significantly prevent the incidence of death, cardiac arrest and other injuries in neonates undergoing cardiac surgery with cardiopulmonary bypass, according to a recent study.
3 days ago
Pulmonary function has potential predictive value for future increases in arterial stiffness and its progression, as reported in a recent study.