Most Read Articles
10 Feb 2019
Living a sedentary lifestyle may increase the risk of cardiovascular diseases (CVD) even in people with healthy body mass index (BMI), reports a new study.
14 Jun 2017
The use of spot urine appears to be unhelpful in estimating 24-hour urinary sodium excretion at the individual level due to its poor performance with regard to misclassification, according to a recent study.
6 days ago
Physician-guided cessation of dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is safe in patients presenting with acute coronary syndrome, a recent study has shown.
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Exosomal microRNAs (miRNAs) in the serum are potential diagnostic biomarkers for Kawasaki disease (KD), a new study shows.

PCSK9 inhibitors safe, effective for familial hypercholesterolaemia

10 Jan 2018

A meta-analysis of 1,526 patients showed that proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitors are safe and effective compared with placebo at reducing LDL-cholesterol (LDL-C) in patients with familial hypercholesterolaemia (FH). [Singh A, et al, AHA 2017, abstract QCOR06]

Researchers from Brigham and Women’s Hospital in Boston, Massachusetts, US, included patients with FH from eight trials that compared PCSK9 inhibitors with standard therapy for at least 12 weeks of follow-up.

Treatment with PCSK9 inhibitors resulted in a mean 48.06 percent reduction in LDL-C compared with placebo.

Besides LDL-C, PCSK9 inhibitors were associated with the largest percent change in non–HDL-cholesterol, followed by apolipoprotein B, total cholesterol, lipoprotein (a), and triglycerides. HDL-cholesterol and Apolipoprotein A1 showed smaller percent increases.

“PCSK9 inhibitors were safe and well tolerated, with injection site reactions being the most common adverse effect,” the researchers said.

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Most Read Articles
10 Feb 2019
Living a sedentary lifestyle may increase the risk of cardiovascular diseases (CVD) even in people with healthy body mass index (BMI), reports a new study.
14 Jun 2017
The use of spot urine appears to be unhelpful in estimating 24-hour urinary sodium excretion at the individual level due to its poor performance with regard to misclassification, according to a recent study.
6 days ago
Physician-guided cessation of dual-antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is safe in patients presenting with acute coronary syndrome, a recent study has shown.
22 Mar 2017
Exosomal microRNAs (miRNAs) in the serum are potential diagnostic biomarkers for Kawasaki disease (KD), a new study shows.