Most Read Articles
6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
08 Jun 2017

Multipoint pacing (MMP) in cardiac resynchronization therapy (CRT) provides significant improvements in left ventricular mechanics and fluid dynamics as compared with biventricular pacing (BiV).

4 days ago
Cognitive impairment appears to be a risk factor for poor adherence to antihypertensive medication among elderly adults without dementia, a recent study has shown.
02 Aug 2018
Intravenous vasodilator therapy confers survival benefits and superior diuretic response in patients with acute heart failure (AHF), provided that systolic (SBP) reduction is <25 percent, according to a posthoc analysis.

PCSK9 inhibitors safe, effective for familial hypercholesterolaemia

10 Jan 2018

A meta-analysis of 1,526 patients showed that proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitors are safe and effective compared with placebo at reducing LDL-cholesterol (LDL-C) in patients with familial hypercholesterolaemia (FH). [Singh A, et al, AHA 2017, abstract QCOR06]

Researchers from Brigham and Women’s Hospital in Boston, Massachusetts, US, included patients with FH from eight trials that compared PCSK9 inhibitors with standard therapy for at least 12 weeks of follow-up.

Treatment with PCSK9 inhibitors resulted in a mean 48.06 percent reduction in LDL-C compared with placebo.

Besides LDL-C, PCSK9 inhibitors were associated with the largest percent change in non–HDL-cholesterol, followed by apolipoprotein B, total cholesterol, lipoprotein (a), and triglycerides. HDL-cholesterol and Apolipoprotein A1 showed smaller percent increases.

“PCSK9 inhibitors were safe and well tolerated, with injection site reactions being the most common adverse effect,” the researchers said.

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Most Read Articles
6 days ago
Patients with coronary artery disease (CAD) treated in a poor Southeast Asian setting appear to have far too high short-term and medium-term mortality rates, according to a study.
08 Jun 2017

Multipoint pacing (MMP) in cardiac resynchronization therapy (CRT) provides significant improvements in left ventricular mechanics and fluid dynamics as compared with biventricular pacing (BiV).

4 days ago
Cognitive impairment appears to be a risk factor for poor adherence to antihypertensive medication among elderly adults without dementia, a recent study has shown.
02 Aug 2018
Intravenous vasodilator therapy confers survival benefits and superior diuretic response in patients with acute heart failure (AHF), provided that systolic (SBP) reduction is <25 percent, according to a posthoc analysis.