Most Read Articles
24 Dec 2017
Losartan at 50 mg is effective in reducing blood pressure in patients with postdialysis euvolemic hypertension, a recent study has shown.
29 Dec 2017
Preoperative hyponatraemia and higher body mass index (BMI) before surgery increase the risk of postoperative stress-related cardiomyopathy (SRC), according to a recent study.
24 Dec 2017
Cardiovascular (CV) diseases or CV risk factors account for the reduced quality of life (QOL) in diabetics compared with nondiabetics, a recent study has found.
24 Dec 2017
The CENTERA transcatheter heart valve (THV) has been proven safe and effective in high-surgical-risk patients with severe symptomatic aortic stenosis at 30 days, resulting in low mortality, significant improvements in haemodynamic outcomes, and low incidence of adverse events, according to a study.

PCSK9 inhibitors safe, effective for familial hypercholesterolaemia

10 Jan 2018

A meta-analysis of 1,526 patients showed that proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitors are safe and effective compared with placebo at reducing LDL-cholesterol (LDL-C) in patients with familial hypercholesterolaemia (FH). [Singh A, et al, AHA 2017, abstract QCOR06]

Researchers from Brigham and Women’s Hospital in Boston, Massachusetts, US, included patients with FH from eight trials that compared PCSK9 inhibitors with standard therapy for at least 12 weeks of follow-up.

Treatment with PCSK9 inhibitors resulted in a mean 48.06 percent reduction in LDL-C compared with placebo.

Besides LDL-C, PCSK9 inhibitors were associated with the largest percent change in non–HDL-cholesterol, followed by apolipoprotein B, total cholesterol, lipoprotein (a), and triglycerides. HDL-cholesterol and Apolipoprotein A1 showed smaller percent increases.

“PCSK9 inhibitors were safe and well tolerated, with injection site reactions being the most common adverse effect,” the researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Cardiology - Malaysia digital copy today!
DOWNLOAD
Editor's Recommendations
Most Read Articles
24 Dec 2017
Losartan at 50 mg is effective in reducing blood pressure in patients with postdialysis euvolemic hypertension, a recent study has shown.
29 Dec 2017
Preoperative hyponatraemia and higher body mass index (BMI) before surgery increase the risk of postoperative stress-related cardiomyopathy (SRC), according to a recent study.
24 Dec 2017
Cardiovascular (CV) diseases or CV risk factors account for the reduced quality of life (QOL) in diabetics compared with nondiabetics, a recent study has found.
24 Dec 2017
The CENTERA transcatheter heart valve (THV) has been proven safe and effective in high-surgical-risk patients with severe symptomatic aortic stenosis at 30 days, resulting in low mortality, significant improvements in haemodynamic outcomes, and low incidence of adverse events, according to a study.