Most Read Articles
15 Nov 2018
In adult cardiac arrest (CA) patients treated with targeted temperature management (TTM), male sex, bystander cardiopulmonary resuscitation (CPR) and the presence of initial shockable rhythm all correlate with greater chances of favourable neurological outcomes, a recent meta-analysis has shown.
Elaine Soliven, 12 Apr 2019
The use of catheter ablation as first-line treatment reduces the number of premature ventricular complexes (PVCs) in a paediatric population, according to a study presented at EHRA 2019.

PCSK9 Inhibitor well tolerated in patients with statin intolerance

17 May 2020

Patients with self-reported statin intolerance may benefit from proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, which have been shown to lower atherogenic lipid markers in this population, suggests a recent study.

The authors conducted a retrospective chart review to describe the tolerability of evolocumab and alirocumab and to examine their efficacy and obtainability. They included adult patients with self-reported statin intolerance who were prescribed a PCSK9 inhibitor. Patient-reported side effects, laboratory values and insurance information were also obtained and assessed.

PCSK9 inhibitor was prescribed to 55 patients during the study period. Forty-two patients initiated therapy, and 34 had at least one follow-up visit. Although adverse events occurred in those prescribed PCSK9 inhibitors, including myalgia (n=5; 14.7 percent), flu-like symptoms (n=4; 11.8 percent) and fatigue (n=1; 2.9 percent), only two patients (5.9 percent) discontinued treatment.

Low-density lipoprotein cholesterol (LDL-C) decreased by 48.7 percent (95 percent confidence interval [CI], –1.7 percent to 99.1 percent). Twenty patients (58.8 percent) were able to achieve a reduction of ≥50 percent in LDL-C.

In terms of obtainability, 44 (77.2 percent) of the 57 prescriptions written required prior authorization. Three (5.3 percent) were denied by insurance.

PCSK9 heightens LDL-C concentrations by interfering with normal physiologic hepatic LDL receptor (LDLR) recycling. By inhibiting PCSK9, LDLR recycling is improved, LDLR availability on hepatocyte cell surfaces is increased and blood LDL-C levels is reduced. This makes PCSK9 inhibition an effective therapeutic strategy for managing hypercholesterolaemia. [Vasc Health Risk Manag 2016;12:185-197]

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Most Read Articles
15 Nov 2018
In adult cardiac arrest (CA) patients treated with targeted temperature management (TTM), male sex, bystander cardiopulmonary resuscitation (CPR) and the presence of initial shockable rhythm all correlate with greater chances of favourable neurological outcomes, a recent meta-analysis has shown.
Elaine Soliven, 12 Apr 2019
The use of catheter ablation as first-line treatment reduces the number of premature ventricular complexes (PVCs) in a paediatric population, according to a study presented at EHRA 2019.