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Pazopanib confers survival benefits in advanced soft tissue sarcoma

08 Dec 2020

Treatment with pazopanib provides clinical benefit in patients with advanced soft tissue sarcoma in a Turkish cohort, with an acceptable safety profile, according to a study.

The investigators conducted this retrospective study to assess the clinical outcomes of Turkish patients with advanced soft tissue sarcoma who received pazopanib. Included patients were aged ≥18 years, had histologically proven advanced soft tissue sarcoma, and received pazopanib at least 1 day.

Seventy-nine patients (median age, 49.6 years) were eligible for analysis. The average dose intensity of pazopanib was 767 mg (400–800), and the median duration of treatment was 6.11 months. Fourteen patients (17.7 percent) used pazopanib as first-line therapy for advanced soft tissue sarcomas.

Pazopanib was well tolerated. Disease progression (89.6 percent) was the most common cause of treatment cessation. Anaemia was the most frequent grade ≥3 side effect, while hyperbilirubinaemia and anaemia were common grade ≤2 side effects.

The median progression-free (PFS) and overall survival (OS) were 3.97 and 11.40 months, respectively, during a median follow-up of 32.72 months. Longer PFS was associated with female gender, good performance status, and the presence of pazopanib-induced hypothyroidism. Longer OS correlated with good performance status and being a responder to first-line treatment.

“This is the first study that suggests pazopanib-induced hypothyroidism may act as a predictive marker for better outcomes in patients with advanced soft tissue sarcoma,” the investigators said.

“Soft tissue sarcomas are a heterogeneous and rare group of cancers with a short median OS despite the chemotherapy. Pazopanib has approval for the treatment of advanced soft tissue sarcoma,” they noted.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 4 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
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Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.