Most Read Articles
Pearl Toh, 20 Apr 2018
The investigational oral synthetic androgen dimethandrolone undecanoate (DMAU) suppresses serum testosterone levels to near castrate levels and appears safe when taken once daily for a month, showing potential as a male contraceptive pill, according to a study.
02 Aug 2018
Men and women who regularly eat seafood appear to have higher sexual intercourse frequency (SIF) and fecundity in a large prospective cohort of couples attempting pregnancy, suggests a study.
12 Apr 2018
In the context of low-glycaemic index (GI) dietary patterns, eating pasta does not contribute to adiposity and may even reduce body weight and body mass index (BMI) compared with higher-GI dietary patterns, a recent study has found.
22 Jun 2018
There appears to be no adverse changes in cardiometabolic markers among individuals with prediabetes or type 2 diabetes (T2D) who consumed a 3-month high-egg weight-loss diet with a 6-month follow-up compared with those who consumed a low-egg weight-loss diet, suggests a recent study.

Patients with young onset diabetes are more sensitive to metformin

03 Dec 2017
Reduced dependence on insulin injections may make patients more inclined to comply with treatment and reduce adverse effects of the injections such as local lipomas or scars.

Young onset type 2 diabetes (YOD) patients appear to be more responsive to metformin, requiring significantly lower insulin with metformin add-on doses than late onset type 2 diabetes (LOD) patients to achieve glycaemic control, a recent study has revealed.

Researchers retrieved medical data of 188 patients who participated in two prior randomized, controlled open-label trials, in which participants received continuous subcutaneous insulin infusion (CSII) with or without metformin.

In the present study, newly diagnosed patients were divided according to age of diabetes onset: before 40 years (YOD; n=36) and after 40 (LOD; n=152). The primary study endpoint was the difference in insulin doses between the two groups.

The time to achieve euglycaemic control was similar between the YOD and LOD groups (4.8±2.4 vs 5.1±2.3 days, respectively). Respective total (0.45±0.27 vs 0.51±024 U/kg/day), basal (0.25±0.17 vs 0.27±0.13 U/kg/day) and bolus (0.22±0.14 vs 0.24±0.16 U/kg/day) insulin doses to maintain glycaemic control were also comparable between groups.

In contrast, those who received CSII with metformin required significantly lower total (0.32±0.15 vs 0.61±0.30 U/kg/day), basal (0.18±0.09 vs 0.33±0.20 U/kg/day) and bolus (0.15±0.06 vs 0.28±0.16 U/kg/day; p<0.01 for all) insulin doses to maintain glycaemic control than those who received insulin alone.

Notably, the total insulin dose required to maintain glycaemic control was also significantly lower in YOD patients on metformin combination therapy than their LOD counterparts (0.32±0.15 vs 0.43±0.15; U/kg/day; p<0.05).

“The data of this current study indicated that newly diagnosed [type 2 diabetes] patients with YOD had a significant increase in metformin sensitivity, which manifested itself when lowering insulin doses to maintain glycaemic control compared to those with a later age of onset of diabetes,” researchers said.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Endocrinology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, 20 Apr 2018
The investigational oral synthetic androgen dimethandrolone undecanoate (DMAU) suppresses serum testosterone levels to near castrate levels and appears safe when taken once daily for a month, showing potential as a male contraceptive pill, according to a study.
02 Aug 2018
Men and women who regularly eat seafood appear to have higher sexual intercourse frequency (SIF) and fecundity in a large prospective cohort of couples attempting pregnancy, suggests a study.
12 Apr 2018
In the context of low-glycaemic index (GI) dietary patterns, eating pasta does not contribute to adiposity and may even reduce body weight and body mass index (BMI) compared with higher-GI dietary patterns, a recent study has found.
22 Jun 2018
There appears to be no adverse changes in cardiometabolic markers among individuals with prediabetes or type 2 diabetes (T2D) who consumed a 3-month high-egg weight-loss diet with a 6-month follow-up compared with those who consumed a low-egg weight-loss diet, suggests a recent study.