Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

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Oestradiol therapy appears to protect certain types of cognition in the presence of stress, suggests a recent study.
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The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.

Patients with young onset diabetes are more sensitive to metformin

03 Dec 2017
Reduced dependence on insulin injections may make patients more inclined to comply with treatment and reduce adverse effects of the injections such as local lipomas or scars.

Young onset type 2 diabetes (YOD) patients appear to be more responsive to metformin, requiring significantly lower insulin with metformin add-on doses than late onset type 2 diabetes (LOD) patients to achieve glycaemic control, a recent study has revealed.

Researchers retrieved medical data of 188 patients who participated in two prior randomized, controlled open-label trials, in which participants received continuous subcutaneous insulin infusion (CSII) with or without metformin.

In the present study, newly diagnosed patients were divided according to age of diabetes onset: before 40 years (YOD; n=36) and after 40 (LOD; n=152). The primary study endpoint was the difference in insulin doses between the two groups.

The time to achieve euglycaemic control was similar between the YOD and LOD groups (4.8±2.4 vs 5.1±2.3 days, respectively). Respective total (0.45±0.27 vs 0.51±024 U/kg/day), basal (0.25±0.17 vs 0.27±0.13 U/kg/day) and bolus (0.22±0.14 vs 0.24±0.16 U/kg/day) insulin doses to maintain glycaemic control were also comparable between groups.

In contrast, those who received CSII with metformin required significantly lower total (0.32±0.15 vs 0.61±0.30 U/kg/day), basal (0.18±0.09 vs 0.33±0.20 U/kg/day) and bolus (0.15±0.06 vs 0.28±0.16 U/kg/day; p<0.01 for all) insulin doses to maintain glycaemic control than those who received insulin alone.

Notably, the total insulin dose required to maintain glycaemic control was also significantly lower in YOD patients on metformin combination therapy than their LOD counterparts (0.32±0.15 vs 0.43±0.15; U/kg/day; p<0.05).

“The data of this current study indicated that newly diagnosed [type 2 diabetes] patients with YOD had a significant increase in metformin sensitivity, which manifested itself when lowering insulin doses to maintain glycaemic control compared to those with a later age of onset of diabetes,” researchers said.

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Most Read Articles
25 Aug 2015
At the Northern Pharmacists Convention cum 48th Malaysian Pharmaceutical Society Seminar 2015 held recently at Bayview Beach Hotel, Penang, Sanofi invited three distinguished speakers – Dr Khaw Chong Hui, Dr Lo Kang Shang Chit, and Professor Dr Karl-Josef Gundermann – to speak on the importance of renal protection in managing diabetic hypertension, the use of antihistamines in managing chronic urticaria (CU), and the role of essential phospholipids (EPL) in fatty liver diseases, respectively.
Roshini Claire Anthony, 07 Nov 2017

Women who are underweight, particularly in their late teens and mid-thirties, may be at risk for early menopause, a recent study found. 

2 days ago
Oestradiol therapy appears to protect certain types of cognition in the presence of stress, suggests a recent study.
17 May 2017
The high-concentration capsaicin patch shows promise in the management of painful diabetic peripheral neuropathy (PDPN), with an effect that is similar to that observed with oral agents but offering systemic tolerability benefits, according to a network meta-analysis.