Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

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Patients with high-risk adenomas more likely to develop, die from colorectal cancers

17 Mar 2020

High-risk adenomas increase the likelihood of developing colorectal cancer and of related death over the long-term, a recent study has found.

Researchers enrolled 64,422 patients (mean age, 61.6±7.1 years; 54.3 percent female) who underwent baseline colonoscopies. Of the participants, 45,881 (71.2 percent) were found to have no adenomas, 10,978 (17.0 percent) had low-risk lesions and 7,563 (11.7 percent) had high-risk adenomas. Patients were followed until death, colorectal cancer development or disenrollment from their health plans.

After a median follow-up of 8.1 years, 117 colorectal cancers were detected in the no-adenoma group, as compared with 37 and 60 in the low- and high-risk groups, respectively. Corresponding numbers of related deaths were 22, 3 and 13.

The researchers found that in the no-adenoma and low-risk groups, the annual, age-adjusted incidence rates of colorectal cancer increased gradually over >10 years of observation. In comparison, values rose steeply in the high-risk group, jumping from 15.0 per 100,000 person-years in year 1 to 217.7 per 100,000 person-years in year 10.

At study end, the cumulative colorectal cancer incidence rates were 0.51 percent, 0.57 percent and 2.03 percent in the no-adenoma, low-risk and high-risk groups, respectively. At this time point, the corresponding related mortality rates were 0.07 percent, 0.03 percent and 0.55 percent.

Adjusted Cox regression analysis confirmed that high-risk adenoma patients were both at greater risk of developing (hazard ratio [HR], 2.61, 95 percent confidence interval [CI], 1.87–3.63) and dying from (HR, 3.94, 95 percent CI, 1.90–6.56) from colorectal cancer. This trend was null in the low-risk group.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.