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Tristan Manalac, 18 Nov 2020
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Patients with hidradenitis suppurativa at risk of developing depression

19 Oct 2020

Hidradenitis suppurativa (HS) in children, adolescents, and adults significantly increases the risk for new-onset depression, independent of other common risk factors for depression, suggests a study.

This retrospective cohort analysis sought to compare the risk of new-onset depression in HS patients with that of control individuals. Using electronic health record data, the investigators identified 49,280 adults and 3,042 paediatric patients with HS and matched controls. Incident depression was the primary outcome.

The crude incidence rate of new-onset depression was 4.8 per 100 person-years in adult patients with HS compared to 3.0 per 100 person-years in control individuals.

Adjusted analysis revealed a 10-percent (hazard ratio [HR], 1.10, 95 percent CI, 1.07–1.13; p<0.001) and 26-percent (HR, 1.26, 95 percent CI, 1.10_1.44; p<0.001) increased risk of developing depression in adults and paediatric patients with HS, respectively, as compared to controls.

Among those with HS, depression was associated with female sex, white race, smoking, and body mass index or obesity in both adults and paediatric patients and with substance abuse in adults only.

These findings support those of a recent systematic review and meta-analysis, which reported a high burden of depression and anxiety among patients with HS. The authors then urged clinicians to be vigilant for the presence of depression or anxiety and to refer patients when appropriate. [J Am Acad Dermatol 2020;83:542-553]

The current study was limited by the absence of patients not seeking care in health systems within the databases in the analysis.

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Most Read Articles
4 days ago
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
3 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

Tristan Manalac, 18 Nov 2020
The substitution of isoleucine to leucine at amino acid 97 (I97L) in the core region of the hepatitis B virus (HBV) seems to reduce its potency, decreasing the efficiency of both infection and the synthesis of the virus’ covalently closed circular (ccc) DNA, reports a new study presented at The Liver Meeting Digital Experience by the American Association for the Study of Liver Diseases (AASLD 2020).