Most Read Articles
07 May 2015
The treatment armamentarium of atopic dermatitis (AD) includes pharmaceuticals like emollients, topical corticosteroids, and topical calcineurin inhibitors. Recently available, medical devices are a newer class of topical, non-steroidal, semi-solid formulation for the treatment of AD and touted to possess emollient, anti-inflammatory, and anti-pruritic properties. To determine the role of medical devices in flare and remission management in AD, a panel of local experts from the field of dermatology, paediatric dermatology, and allergy convened to review the available evidence and highlights of the meeting are reported here.
4 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.
24 Nov 2017
It appears that patients with psoriasis have lesser health-related quality of life (HRQoL) burden than those with hidradenitis suppurativa (HS), a recent study has found.
12 Nov 2017
Active and passive smoking are associated with atopic dermatitis, a new study from Korea reveals.

Patients with genital melanosis may need careful examinations for melanoma

20 Apr 2017

A careful total body examination may be required in patients with genital melanosis, particularly those with any level of histologic atypia in the genital melanosis lesion, for the possibility of melanoma in any body site, according to a recent study.

To determine the potential risk for genital and nongenital melanoma in patients, a retrospective cohort study was conducted. The authors analysed clinical and histologic data from patients (n=41) with genital melanosis to better describe these lesions and the risk they confer for genital and nongenital melanoma.

Genital melanosis may clinically mimic melanoma, according to researchers. However, its typical age of onset is younger than for genital melanoma.

A majority of lesions stabilized or regressed over time. There were five patients found to have a history of melanoma, one of which was in the genital region. Lesions from these patients were more likely to show melanocytes with suprabasal movement (p=0.0101) and to have a higher melanocyte count (p<0.0462).

This study was limited by the relatively small cohort of patients with an average follow-up of only 30.5 months, researchers said.

A previous study had shown that reflectance confocal microscopy could noninvasively differentiate between vulvar melanoma and vulvar melanosis. Two major features were identified with vulvar melanosis: papillae rimmed by bright monomorphous cells and possible presence of a few dendritic bright cells in the basal layer of the epithelium. Vulvar melanoma was also associated with two major characteristics: atypical cells in the epithelium and loss of normal architecture of chorion papillae. [Dermatol Surg 2012;38:1962-7]

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Most Read Articles
07 May 2015
The treatment armamentarium of atopic dermatitis (AD) includes pharmaceuticals like emollients, topical corticosteroids, and topical calcineurin inhibitors. Recently available, medical devices are a newer class of topical, non-steroidal, semi-solid formulation for the treatment of AD and touted to possess emollient, anti-inflammatory, and anti-pruritic properties. To determine the role of medical devices in flare and remission management in AD, a panel of local experts from the field of dermatology, paediatric dermatology, and allergy convened to review the available evidence and highlights of the meeting are reported here.
4 days ago
Hydrochlorothiazide (HCTZ) appears to significantly increase the risks of nonmelanoma skin cancer (NMSC), particularly squamous cell carcinoma (SCC), a recent study has shown.
24 Nov 2017
It appears that patients with psoriasis have lesser health-related quality of life (HRQoL) burden than those with hidradenitis suppurativa (HS), a recent study has found.
12 Nov 2017
Active and passive smoking are associated with atopic dermatitis, a new study from Korea reveals.