Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Patients with gastric dysplasia at risk of progression to gastric adenocarcinoma

06 Sep 2019

Gastric dysplasia (GD), specifically high-grade lesions, appears to carry an elevated risk of progression to gastric adenocarcinoma (GAC), according to the results of a meta-analysis.

Researchers searched multiple online databases for studies reporting the incidence rate of GAC among patients with GD. They used Cochran Q and I tests to evaluate heterogeneities between included studies.

Of the 1,980 records retrieved, 30 articles (61 studies) were included in the meta-analysis. Data were pooled using random-effect or fixed-effect models.

The overall pooled incidence rate of GAC in patients with GD was 40.36 (95 percent CI, 27.08–55.71; I2, 96.0 percent) cases per 1,000 person-years. Subgroup analysis defined according to the type of GD revealed the highest GAC incidence among patients with high-grade dysplasia (HGD) lesions (186.40 per 1,000 person-years, 106.63–285.60; I2, 94.6 percent). Among low-grade dysplasia (LGD) and nonclassified lesions, the corresponding incidence rates were 11.25 (3.91–21.22; I2, 89.3 percent) and 1.40 (0.00–9.71; I, 78.8 percent) per 1,000 person-years.

Of note, patients with HGD were about 16 times as likely as those with LGD lesions to progress from GD to GAC.

The current findings highlight the importance of strict management of HGD lesions to prevent GAC, as the majority of patients with GAC are diagnosed in an advanced stage, the researchers said.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.