Most Read Articles
Roshini Claire Anthony, 23 Nov 2017

The long-term mortality benefit conferred by mechanical over biologic prosthesis in valve replacement appears to be age- and location-dependent, according to findings of a US-based retrospective study.  

10 Jan 2018
Shared decision support with the use of standardized decision aids improves decision quality and reduces implantation of left ventricular assist device as destination therapy (DT-LVAD) in patients with advanced heart failure.
Pearl Toh, 6 days ago
The protective effects of liraglutide against the risks of cardiovascular (CV) events and deaths may be reduced in patients with type 2 diabetes (T2D) who experienced severe hypoglycaemia, but were independent of patient’s history of CV events at baseline, according to post hoc analyses of the LEADER* trial.
01 Aug 2015
A higher prevalence of coronary artery disease was reported among adult men than women with Kawasaki disease, a study shows.

Patients with cancer face heightened short-term risk of arterial thromboembolism

25 Aug 2017

There is a markedly increased short-term risk of arterial thromboembolism among patients with incident cancer, a recent study has found.

To improve understanding of the epidemiological relationship between arterial thromboembolism and cancer, researchers identified patients with a new primary diagnosis of breast, lung, prostate, colorectal, bladder, pancreatic or gastric cancer or non-Hodgkin lymphoma from 2002 to 2011 using the Surveillance Epidemiology and End Results–Medicare linked database.

The authors individually matched patients by demographics and comorbidities to a Medicare enrolee without cancer, and followed each pair through 2012.

Arterial thromboembolism, defined as myocardial infarction or ischaemic stroke, was identified using validated diagnosis codes. Competing risk survival statistics was used to calculate cumulative incidence rates. Cox hazards analysis was performed to compare rates between groups at discrete time points.

In total, 279,719 pairs of patients with cancer and matched controls were included. Patients with cancer had higher 6-month cumulative incidence of arterial thromboembolism than controls (4.7 percent; 95 percent CI, 4.6 to 4.8 percent vs 2.2 percent; 2.1 to 2.2 percent; hazard ratio [HR], 2.2; 2.1 to 2.3).

The 6-month cumulative incidence of myocardial infarction was 2.0 percent (1.9 to 2.0 percent) vs 0.7 (0.6 to 0.7 percent) in patients with cancer and control patients, respectively (HR, 2.9; 2.8 to 3.1). The 6-month cumulative incidence of ischaemic stroke was 3.0 percent (2.9 to 3.1 percent) in patients with cancer vs 1.6 percent (1.6 to 1.7 percent) in controls (HR, 1.9; 1.8 to 2.0).

Excess risk varied by cancer type (highest for lung), was associated with cancer stage and had largely resolved by 1 year, according to researchers.

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Most Read Articles
Roshini Claire Anthony, 23 Nov 2017

The long-term mortality benefit conferred by mechanical over biologic prosthesis in valve replacement appears to be age- and location-dependent, according to findings of a US-based retrospective study.  

10 Jan 2018
Shared decision support with the use of standardized decision aids improves decision quality and reduces implantation of left ventricular assist device as destination therapy (DT-LVAD) in patients with advanced heart failure.
Pearl Toh, 6 days ago
The protective effects of liraglutide against the risks of cardiovascular (CV) events and deaths may be reduced in patients with type 2 diabetes (T2D) who experienced severe hypoglycaemia, but were independent of patient’s history of CV events at baseline, according to post hoc analyses of the LEADER* trial.
01 Aug 2015
A higher prevalence of coronary artery disease was reported among adult men than women with Kawasaki disease, a study shows.