Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.
Jackey Suen, 01 Mar 2013

The first consensus statement on the appropriate use of biologics for the treatment of inflammatory bowel disease (IBD) in Hong Kong is now available. [Hong Kong Med J 2013;19:61-68]

Patients with ankylosing spondylitis face long, frequent flares

13 Apr 2017

Flares are common and long in patients with ankylosing spondylitis (AS) before the wide use of biologics, according to a Canada study.

To examine the frequency of patient-reported flares and their related factors, researchers conducted a cross-sectional study using 2004 data of a Canadian cohort with AS according to the modified New York criteria (n=234; mean age 45.5 years; 73.5 percent males).

They assessed the participants’ current flare status (“Are you experiencing a current flare?”), number of flares over the past 3 months, average duration, Bath Ankylosing Spondylitis Disease Activity and Functional Index (BASDAI and BASFI, respectively), and AS Quality of Life questionnaire by self-report. Factors linked to current flare were analysed using univariate and multivariate regressions.

AS patients had a mean disease duration of 21.7 years, and mean BASDAI and BASFI (0 to 10) of 4.4 and 3.4, respectively. There were 18 (7.7 percent) patients who received antitumour necrosis factor (anti-TNF).

Of the analysed patients, 175 (74.8 percent) reported flares and 117 (50 percent) were currently in flare. Those who reported flares had a median of three occurrences in 3 months, with a median duration of 2 weeks. As a whole, all 234 patients spent a median of 25 percent of their time in flare.

Based on multivariate analyses, current flare was significantly associated with higher BASDAI (odds ratio [OR], 2.01; p=0.01), worse quality of life (OR, 1.37; p=0.004), shorter AS duration (OR, 1.19; p=0.04) and less anti-TNF (OR, 7.14; p=0.03).

“As expected, flare was associated with higher disease activity, suggesting the validity of the concept of patient-reported flares,” researchers said.

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Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.
Jackey Suen, 01 Mar 2013

The first consensus statement on the appropriate use of biologics for the treatment of inflammatory bowel disease (IBD) in Hong Kong is now available. [Hong Kong Med J 2013;19:61-68]