Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.

Patient-reported outcomes hardly predict RA change in disease activity

06 Sep 2017

It appears that patient-reported pain, stiffness and fatigue at baseline offer limited value for the prediction of changes in disease activity and activity limitation in early rheumatoid arthritis (RA), according to a recent study.

Researchers recruited cases (n=1,415) to the Yorkshire Earl Arthritis Register between 1997 and 2009 to evaluate patient-reported variables as predictors of change in disease activity and disability in RA. Multilevel models were used to identify Predictors of the 28-joint Disease Activity Score (DAS28) and the Health Assessment Questionnaire-Disability Index (HAQ-DI) at baseline and change over 12 months.

The baseline predictors were the following: age, sex, symptom duration, autoantibody status, pain and fatigue visual analogue scales (VAS), DAS28, HAQ-DI, and duration of early morning stiffness (EMS).

Women had slower rates of change than men: DAS28 dropped by 0.19 and 0.17 units/month, and HAQ-DI by 0.028 and 0.023 units/month in men and women, respectively. The effects of baseline pain and EMS on rates of change were small, while fatigue VAS was only associated with DAS28 and HAQ-DI at baseline.

In patients recruited up to 2002, those with greater pain at baseline reduced DAS28 more quickly (by 0.01 unites/month of DAS28 per cm pain VAS; p=0.024). In patients recruited after 2002, there was a stronger effect for pain (by 0.01 units/month; 0.087).

Reduction in DAS28 was greater with longer EMS. In both cohorts, patients with longer EMS duration had greater reduction in HAQ-DI (p=0.006). However, pain and fatigue were not significant predictors of change in HAQ-DI, according to researchers.

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Most Read Articles
01 Nov 2013

Joint stiffness is defined as discomfort after a period of inactivity. It is associated with reduced or loss of range of motion in a joint.

Stephen Padilla, 25 Nov 2016
The addition of supervised physiotherapy to usual care does not provide clinically important improvement in the management of simple ankle sprains in a general population of patients seeking hospital-based acute care, according to results of a recent randomized controlled trial.
24 Jul 2017
The toxic side-effects of chemotherapy appear to be induced by cell-free chromatin (cfCh) fragments released from dying cells, triggering DNA damage, apoptosis and inflammation in healthy cells, thereby exaggerating or amplifying the toxic effects caused by the drugs themselves, according to a study.