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Paternal overweight, obesity contribute to LGA risk after frozen embryo transfer

31 May 2020

A high body mass index (BMI) among fathers appears to be a risk factor for a large for gestational age (LGA) outcome after frozen embryo transfer (FET), according to a study.

Researchers looked at 7,908 singleton newborns, among whom 284 (3.6 percent) had paternal BMI in the underweight category, 4,678 (59.2 percent) in the normal category, 2,585 (32.7 percent) in the overweight category, and 361 (4.6 percent) in the obesity category.  

The mean paternal BMI was 24.12 kg/m2. Men with normal weight were slightly older (33.86 5.29 years) than those who were underweight but were slightly younger than those in the higher BMI categories. Men who were overweight or obese were more likely to be smokers than those who were of normal weight.

As earlier indicated, the proportion of LGA infants was significantly higher in the paternal overweight and obesity categories than in the paternal underweight category. The proportion was also higher in the paternal overweight category but lower in the paternal underweight category than in the normal-weight reference.

Meanwhile, the rates of foetal macrosomia were higher in the paternal overweight than in the normal weight category. Z-scores (gestational age- and sex-adjusted birthweight) were significantly higher among infants with overweight or obese fathers than among those whose fathers had normal weight.

Multiple linear regression model revealed a positive association between paternal BMI and newborn birthweight.

Additional studies with large sample sizes are needed to examine whether the differences in birthweight observed in the current study have implications for the risk of complications during the foetal and neonatal periods and many diseases in adulthood, the researchers said.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Stephen Padilla, 15 Jun 2020
Consumption of whole almonds as snacks not only reduces low-density lipoprotein cholesterol (LDL-C) but also significantly improves endothelial function in adults with above-average risk of cardiovascular disease (CVD), according to the results of a trial.
Pearl Toh, 2 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.