Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Patent foramen ovale predicts decompression sickness in casual divers

24 Oct 2019
The ups and downs of diving: Great for heart health, despite high injury risk

High-grade patent foramen ovale (PFO) is a strong risk factor for unprovoked decompression sickness (DCS) among recreational scuba divers, a recent study has found.

Using transcranial color-coded Doppler sonography, researchers screened 489 consecutive divers (mean age, 35.6±9.0 years; 86.5 percent male) for PFO. DCS history at baseline was collected from all participants at the time of screening. Unprovoked DCS was defined as symptoms occurring <24 hours after a dive that was compliant with all safety rules and guidelines. Those that developed with the background of severe exhaustion or inadequate hydration were considered provoked DCS.

Forty percent of the divers were positive for a PFO, while 7 percent suffered from an unprovoked DCS. There was a total of 54 unprovoked DCS episodes reported across a total of 169,411 dives. The occurrence rate per dive was 0.03 percent.

Almost all the divers with a history of unprovoked DCS had a PFO (97 percent), as opposed to only 36 percent in the no-episode controls (p<0.001). This was also true for grade 3 PFOs (86 percent vs 18 percent; p<0.001).

Cox proportional hazards analysis found that PFO was a significant risk factor for unprovoked DCS (adjusted hazard ratio [HR], 60.0, 95 percent CI, 8.2–438.5; p<0.001), as was grade 3 PFO (adjusted HR, 93.0, 12.5–688.7; p<0.001). Low-grade DCS likewise emerged as a nominal risk factor, but was only of borderline significance (adjusted HR, 10.8, 1.0–121.8; p=0.054).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.