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Passive smoking, family history up risk of gestational diabetes mellitus

08 Jun 2018

Passive smoking at home and in the workplace as well as having a family history of diabetes mellitus increase the risk of gestational diabetes mellitus (GDM), according to a recent China study.

Researchers recruited pregnant women with (n=276; mean age 29.31±4.30 years) and without (n=276; mean age 29.32±4.30 years) GDM and sought to identify the socioeconomic, lifestyle and environmental factors tied to GDM risk. These included environmental tobacco smoke (ETS) exposure, alcohol consumption, physical activity, education and occupation, among others.

In the final best-fit model including all variables across the domains of socioeconomic, biological, and environmental and lifestyle factors, only passive smoking at home from the husband (odds ratio [OR], 1.52;95 percent CI, 1.05–2.20; p=0.027), passive smoking in the workplace (OR, 1.71; 1.14–2.56; p=0.010) and a family history of diabetes in first-degree relatives (OR, 3.07; 1.44–6.55; p=0.004) were correlated with elevated GDM risk.

Analysis of factors per domain showed that among the socioeconomic factors associated with GDM were high educational attainment (OR, 2.13; 1.36–3.34; p=0.001), high household incomes (≥9,000 Yuan/month; OR, 2.64; 1.43–4.86; p=0.002) and >5 years of residency in Beijing (OR, 1.57; 1.08–2.27; p=0.018).

Moreover, alcohol consumption prior to (OR, 1.77; 1.13–2.77; p=0.013) and during (OR, 1.76; 1.03–3.01; p=0.038) pregnancy, as well as passive smoking at home (OR, 1.58; 1.11–2.25; p=0.011) and at the workplace (OR, 1.68; 1.13–2.49; p=0.009), also increased the likelihood of GDM.

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