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Pancreatic fat volume may predict deterioration of beta cell function in type 2 diabetics

21 Mar 2020
Type 3c diabetes is caused by injury to the pancreas, and is often misdiagnosed as type 2 diabetes.

Pancreatic fat volume (PFV) may be indicative of worsening beta-cell dysfunction in type 2 diabetes patients, reports a new study.

Researchers cross-sectionally examined 132 consecutive type 2 diabetes patients (mean age, 63.7±14.0 years; 64.4 percent male), in whom multidetector computed tomography (MDCT) was used to measure PFV, total pancreatic volume (TPV), pancreatic parenchymal volume (PPV) and visceral fat volume. The C-peptide immunoreactivity (CPR) index and CPR-insulin resistance (CPR-IR) were used as markers of insulin secretion and sensitivity, respectively.

TPV, PFV and PPV were all significantly correlated with body weight (BW; p<0.0001 for all) and were thus adjusted for it for the subsequent analyses.

TPV/BW and PFV/BW were both significantly and positively associated with CPR index (p<0.005), while PPV/BW was not. In comparison, TPV/BW and PFV/BW, but not PPV/BW, were inversely correlated with CPR-IR.

Subsequently, participants were divided according to the median PFV-to-TPV ratio. In those above the median value, CPR index was significantly lower in patients with diabetes duration >5 vs 5 years. This effect was absent in the low-PFV/TPV subgroup. Similarly, CPR index in the high-PFV/BW group was significantly decreased in patients with disease duration >5 vs 5 years.

“[O]ur present study suggests that pancreatic fat accumulation might be attributable to longitudinal decline in beta cell function in type 2 diabetic patients with insulin resistance,” said the searchers. “Evaluation of PFV by MDCT may help identify diabetic patients who benefit most from improvement of central obesity.”

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Most Read Articles
3 days ago
Diabetes mellitus (DM) may contribute to complications in head and neck cancer (HNC) patients undergoing concurrent chemoradiotherapy (CCRT), a recent study has found.
Pearl Toh, 14 May 2020
Children with high serum insulin levels and whose parents are under stress are more likely to have asthma symptoms, suggest two studies presented at the AAAAI 2020 Meeting.