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Palivizumab immunization in extremely premature babies exerts null effect on pulmonary outcomes

07 May 2020

In infants born extremely premature, immunization with palivizumab does not confer apparent protective effects on respiratory symptoms and pulmonary function at adolescence, as reported in a recent study. Nevertheless, immunized survivors of extreme prematurity show good clinical and physiological outcomes.

The study included 64 adolescents (mean age, 15.76 years), among whom 46 survived extreme prematurity (<29 weeks; study group) and 18 were born at term (control group). Of the children in the study group, 17 received palivizumab (PG) and 29 did not (NPG).

Wheezing episodes, inhaler use and hospitalizations were uncommon in the study group. Compared with teens who were born at term, those born extremely preterm had significantly lower predicted forced expiratory volume in the first second (FEV1%) value (mean, 82.60 percent vs 105.83 percent; p<0.001) but similar lung clearance index (LCI; mean, 7.67 vs 7.46; p=0.48).

However, in study group, adolescents with vs without bronchopulmonary dysplasia had a markedly higher LCI (mean, 7.94 vs 7.20; p=0.002). There were no significant differences observed between PG and NPG adolescents.

In the study group overall, airway hyper reactivity detected at primary school age decreased by adolescence. Specifically, significant improvements were seen in mean FEV1% predicted bronchodilator response (0.37 percent vs 5.67 percent; p=0.036) and in mean concentration of methacholine needed to produce a 20-percent drop in FEV1 (PC20; 12.16 vs 4.14 mg/ml; p<0.001).

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Most Read Articles
29 Jul 2020
Adjunctive perampanel appears to be safe and effective for long-term treatment of patients with tonic‐clonic seizures, according to a posthoc analysis.
Pearl Toh, 5 days ago
The direct oral anticoagulant apixaban may help prevent deaths when given at prophylactic or therapeutic doses in hospitalized COVID-19 patients with elevated D-dimer levels, according to an analysis presented during the ISTH 2020 Congress.
Elvira Manzano, 20 Jun 2018
A higher proportion of patients with systemic lupus erythematosus (SLE) experienced improvements in joint and skin symptoms with baricitinib 4 mg once daily vs placebo in a phase II randomized, double-blind, global study.