Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Jairia Dela Cruz, 27 Mar 2020
Use of antioxidants for treating male factor infertility appears to be of little benefit, improving neither semen parameters nor DNA integrity, according to the results of the Males, Antioxidants and Infertility (MOXI) trial.

Palivizumab immunization in extremely premature babies exerts null effect on pulmonary outcomes

07 May 2020

In infants born extremely premature, immunization with palivizumab does not confer apparent protective effects on respiratory symptoms and pulmonary function at adolescence, as reported in a recent study. Nevertheless, immunized survivors of extreme prematurity show good clinical and physiological outcomes.

The study included 64 adolescents (mean age, 15.76 years), among whom 46 survived extreme prematurity (<29 weeks; study group) and 18 were born at term (control group). Of the children in the study group, 17 received palivizumab (PG) and 29 did not (NPG).

Wheezing episodes, inhaler use and hospitalizations were uncommon in the study group. Compared with teens who were born at term, those born extremely preterm had significantly lower predicted forced expiratory volume in the first second (FEV1%) value (mean, 82.60 percent vs 105.83 percent; p<0.001) but similar lung clearance index (LCI; mean, 7.67 vs 7.46; p=0.48).

However, in study group, adolescents with vs without bronchopulmonary dysplasia had a markedly higher LCI (mean, 7.94 vs 7.20; p=0.002). There were no significant differences observed between PG and NPG adolescents.

In the study group overall, airway hyper reactivity detected at primary school age decreased by adolescence. Specifically, significant improvements were seen in mean FEV1% predicted bronchodilator response (0.37 percent vs 5.67 percent; p=0.036) and in mean concentration of methacholine needed to produce a 20-percent drop in FEV1 (PC20; 12.16 vs 4.14 mg/ml; p<0.001).

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Most Read Articles
Elaine Soliven, 20 May 2020
Early treatment with a triple antiviral combination of lopinavir-ritonavir, ribavirin, and interferon beta-1b significantly shortens the duration of virus shedding and reduces symptoms in patients with mild-to-moderate COVID-19 compared with lopinavir-ritonavir only, according to a recent study.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
Roshini Claire Anthony, 27 May 2020

The use of a vaginal cleansing intervention prior to Caesarean delivery reduced the incidence of surgical site infections (SSIs), according to a study presented at ACOG 2020. However, the addition of intravenous (IV) azithromycin prophylaxis had no added impact on SSI rates. 

Jairia Dela Cruz, 27 Mar 2020
Use of antioxidants for treating male factor infertility appears to be of little benefit, improving neither semen parameters nor DNA integrity, according to the results of the Males, Antioxidants and Infertility (MOXI) trial.