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Pain, erosion in joints common in accelerated hand osteoarthritis

21 Apr 2019

Hand joints can develop accelerated osteoarthritis (OA), particularly among digits commonly used for pinching and fine motor skills, a recent study has found.

To determine whether hand joints develop an accelerated form of OA and to characterize individuals who develop accelerated hand (AH) OA, the investigators analysed 3,519 participants in the Osteoarthritis Initiative with complete data for baseline and 48-month radiographic hand OA.

Using a modified Kellgren-Lawrence (KL) scale, one reader scored posteroanterior radiographs of the dominant hand, and another scored the presence of central or marginal erosions. A third reader worked on images flagged for signs of diseases other than OA.

AHOA was defined as ≥1 joint that progressed from a KL grade of 0 or 1 at baseline to a KL grade of 3 or 4 at 48 months.

Over 4 years, 1 percent of the participants met the AHOA definition: 37 hands had one joint affected, and one hand had two joints affected.

Adults who developed AHOA, compared with those who did not, were more likely to have hand pain (37 percent vs 22 percent), radiographic hand OA (71 percent vs 3 percent), and central (22 percent vs 7 percent) and marginal erosions (11 percent vs 2 percent) in other joints at baseline.

New erosions were more likely to develop in adults with AHOA (central, 35 percent; marginal, 5 percent) than those without (central, 5 percent; marginal, 1 percent) over 48 months.

The second metacarpophalangeal and first carpometacarpal joint were the most common locations of accelerated OA, according to the investigators.

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Most Read Articles
4 days ago
In patients with type 2 diabetes, obesity may be protective against vision-threatening diabetic retinopathy, a recent Korea study has shown.
10 Jun 2019
Atrial fibrillation (AF) carries an excess risk of stroke recurrence independent of comorbidity with and heart failure (HF), while HF without AF also poses a significant risk of recurrence, a study has shown.
Roshini Claire Anthony, 3 days ago

Men with metastatic hormone-sensitive prostate cancer (mHSPC) who receive testosterone suppression therapy may have a better survival outcome with the addition of enzalutamide over other non-steroidal anti-androgen (NSAA) therapies, according to the phase III ENZAMET* trial.

07 Jun 2019
Low-dose aspirin therapy does not confer significant benefits to elderly patients with hypertension, but treatment appears to increase the risk of haemorrhagic events, suggest a Japan study.