Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 3 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 4 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Pain, erosion in joints common in accelerated hand osteoarthritis

21 Apr 2019

Hand joints can develop accelerated osteoarthritis (OA), particularly among digits commonly used for pinching and fine motor skills, a recent study has found.

To determine whether hand joints develop an accelerated form of OA and to characterize individuals who develop accelerated hand (AH) OA, the investigators analysed 3,519 participants in the Osteoarthritis Initiative with complete data for baseline and 48-month radiographic hand OA.

Using a modified Kellgren-Lawrence (KL) scale, one reader scored posteroanterior radiographs of the dominant hand, and another scored the presence of central or marginal erosions. A third reader worked on images flagged for signs of diseases other than OA.

AHOA was defined as ≥1 joint that progressed from a KL grade of 0 or 1 at baseline to a KL grade of 3 or 4 at 48 months.

Over 4 years, 1 percent of the participants met the AHOA definition: 37 hands had one joint affected, and one hand had two joints affected.

Adults who developed AHOA, compared with those who did not, were more likely to have hand pain (37 percent vs 22 percent), radiographic hand OA (71 percent vs 3 percent), and central (22 percent vs 7 percent) and marginal erosions (11 percent vs 2 percent) in other joints at baseline.

New erosions were more likely to develop in adults with AHOA (central, 35 percent; marginal, 5 percent) than those without (central, 5 percent; marginal, 1 percent) over 48 months.

The second metacarpophalangeal and first carpometacarpal joint were the most common locations of accelerated OA, according to the investigators.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 3 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 4 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.