Most Read Articles
11 Aug 2020
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Elaine Soliven, 3 days ago
Adding mepolizumab to standard of care treatment significantly reduces nasal polyp size and obstruction in adults with chronic rhinosinusitis with nasal polyps (CRSwNP), according to the SYNAPSE* study presented at ERS 2020.
5 days ago
OZEMPIC – Semaglutide 1.34 mg/mL soln for inj
Audrey Abella, 11 Sep 2020
A prasugrel de-escalation strategy significantly reduced the risk of NACE* and bleeding events in patients with ACS** after PCI*** compared with the conventional strategy, results of the HOST-REDUCE-POLYTECH-ACS# trial have shown.

Paediatric UTI pathogens respond well to aminopenicillin, β-lactamase inhibitors

09 May 2020
Pathogens behind paediatric febrile urinary tract infections (UTIs) show a satisfactory in vitro susceptibility profile to first-line therapy with a combination of aminopenicillin and β-lactamase inhibitors (BLI), a new study has shown.

Researchers conducted a retrospective analysis of 590 children (aged 0–18 years; 66.1 percent female) with acute pyelonephritis from whom urine samples were collected, were cultured and tested positive. Antimicrobial testing was performed through agar disk diffusion.

Majority of the samples were positive for Escherichia coli (60.8 percent). Other common uropathogens were Enterococcus spp (13.3 percent), Klebsiella spp (7.0 percent), Proteus spp (5.2 percent) and Pseudomonas aeruginosa (4.2 percent).

E. coli had an 81.0 percent sensitivity to aminopenicillin/BLI. Without the BLI add-ons, sensitivity dropped to 57.1 percent. Second and third generation cephalosporins, carbapenems, quinolones and aminoglycosides proved to be even more powerful against E. coli, which was >90 percent sensitive.

Over the 10-year period from 2009 to 2018, E. coli showed an average sensitivity to aminopenicillin/BLI of 81.0 percent. Though a rapid decrease to 64.3 percent sensitivity was observed since 2014, this was not accompanied by changes in clinical response rate.

Enterococcus spp cultures were 96.8 percent sensitive to ampicillin, but resistant to cotrimoxazole in 14.9 percent. Klebsiella spp, intrinsically resistant to ampicillin, also showed a 6.1-percent resistance rate against aminopenicillin/BLI. However, Klebisiella spp showed high sensitivity to cephalosporins, carbapenems and quinolones.

Proteus spp samples were 45.9 percent resistant to cotrimoxazole and intrinsically resistant against nitrofurantoins.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Pharmacist - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
11 Aug 2020
During the Allergic Rhinitis (AR) Boot Camp held in conjunction with the Bayer Pharmacist Congress 2020, Professor Dr Baharudin Abdullah discussed the management of AR in the primary care setting and the importance of using patient profiles to guide the choice of antihistamines.
Elaine Soliven, 3 days ago
Adding mepolizumab to standard of care treatment significantly reduces nasal polyp size and obstruction in adults with chronic rhinosinusitis with nasal polyps (CRSwNP), according to the SYNAPSE* study presented at ERS 2020.
5 days ago
OZEMPIC – Semaglutide 1.34 mg/mL soln for inj
Audrey Abella, 11 Sep 2020
A prasugrel de-escalation strategy significantly reduced the risk of NACE* and bleeding events in patients with ACS** after PCI*** compared with the conventional strategy, results of the HOST-REDUCE-POLYTECH-ACS# trial have shown.