Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Stephen Padilla, 3 days ago
High-flow oxygen is not associated with an increase or a decrease in 30-day mortality, suggesting no benefit in most patients presenting with a suspected acute coronary syndrome (ACS), reports a New Zealand study.

Paediatric-onset IBD linked to cancer risk

07 Feb 2021

Patients with paediatric-onset inflammatory bowel disease (IBD) suffer from a greater risk of developing malignancies, reports a new meta-analysis.

Sixty-six eligible studies were retrieved from the databases of Embase, PubMed/Medline, Scopus, Google Scholar, and the Cochrane Central Register of Controlled Trials. Overall, 38,092 patients were included. Only those that diagnosed IBD before the age of 18 years were eligible.

Six retrospective observational studies (n=17,450) reported cancer risk as standardized incidence ratio (SIR). Four studies found that patients with Crohn’s disease (CD) were more than twice as likely to develop cancer (pooled SIR, 2.42, 95 percent confidence interval [CI], 1.90–3.06; p<0.0001), and five studies showed similar estimates for ulcerative colitis (UC: pooled SIR, 2.10, 95 percent CI, 1.51–2.90; p<0.0001).

In the overall paediatric IBD sample, the pooled SIR of cancer was 2.39 (95 percent CI, 2.00–2.86; p<0.0001).

Subsequent analyses included nine prospective and 44 retrospective studies that reported incidence rates for all cancers in paediatric IBD patients. The pooled incidence rates in those with CD and UC were 0.014 (95 percent CI, 0.0087–0.021) and 0.031 (95 percent CI, 0.018–0.052), respectively. Site-specific malignancies, such as colorectal cancer and haematologic cancers, also occurred more frequently in paediatric IBD patients.

“[T]his systematic review and meta-analysis showed that patients with IBD diagnosed in childhood have an increased risk of cancers when compared with the general population. This risk appeared to be attributed mostly to the development of CRC and hematologic cancers,” researchers said.

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Most Read Articles
Roshini Claire Anthony, 3 days ago

The addition of methylprednisolone to standard care* reduced mortality risk in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), according to a study from China.

05 Feb 2021

Primary immunodeficiency disease (PIDD) and allergies are two groups of conditions related to the immune system. However, they are uniquely different in terms of symptoms and treatment.

Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
Stephen Padilla, 3 days ago
High-flow oxygen is not associated with an increase or a decrease in 30-day mortality, suggesting no benefit in most patients presenting with a suspected acute coronary syndrome (ACS), reports a New Zealand study.